Seroatlas · Human Serome Atlas

SNX6

Sorting nexin-6

Also known as: SNX6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNH7
Gene
SNX6
Ensembl
ENSG00000129515
Chromosome
14
Canonical length
406 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Endosomes,Lysosomes

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9UNH7|SNX6
     1  MMEGLDDGPD FLSEEDRGLK AINVDLQSDA ALQVDISDAL SERDKVKFTV HTKSSLPNFK
    61  QNEFSVVRQH EEFIWLHDSF VENEDYAGYI IPPAPPRPDF DASREKLQKL GEGEGSMTKE
   121  EFTKMKQELE AEYLAIFKKT VAMHEVFLCR VAAHPILRRD LNFHVFLEYN QDLSVRGKNK
   181  KEKLEDFFKN MVKSADGVIV SGVKDVDDFF EHERTFLLEY HNRVKDASAK SDRMTRSHKS
   241  AADDYNRIGS SLYALGTQDS TDICKFFLKV SELFDKTRKI EARVSADEDL KLSDLLKYYL
   301  RESQAAKDLL YRRSRSLVDY ENANKALDKA RAKNKDVLQA ETSQQLCCQK FEKISESAKQ
   361  ELIDFKTRRV AAFRKNLVEL AELELKHAKG NLQLLQNCLA VLNGDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 74 nTPM
  • placenta: 70 nTPM
  • duodenum: 70 nTPM
  • spinal cord: 65 nTPM
  • lymph node: 53 nTPM
  • colon: 47 nTPM

Single-cell type

  • hofbauer cells: 472 nCPM
  • syncytiotrophoblasts: 409 nCPM
  • kupffer cells: 385 nCPM
  • neutrophils: 311 nCPM
  • esophageal apical cells: 279 nCPM
  • macrophages: 268 nCPM

Immune cell

  • neutrophil: 127 nTPM
  • total PBMC: 109 nTPM
  • T-reg: 102 nTPM
  • non-classical monocyte: 102 nTPM
  • intermediate monocyte: 98 nTPM
  • memory CD4 T-cell: 97 nTPM

Brain region

  • white matter: 62 nTPM
  • medulla oblongata: 52 nTPM
  • spinal cord: 51 nTPM
  • pons: 49 nTPM
  • basal ganglia: 49 nTPM
  • midbrain: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.5
gnomAD missense Z
1.51
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX6 as an antibody target. Whether an autoantibody or antibody against SNX6 could matter depends on whether native SNX6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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