Seroatlas · Human Serome Atlas

ACAP1

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Also known as: ACAP1_HUMAN, CENTB1, KIAA0050

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15027
Gene
ACAP1
Ensembl
ENSG00000072818
Chromosome
17
Canonical length
740 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable GTPase activator activity and zinc ion binding activity. Predicted to be involved in protein transport. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

740 residues, UniProt reviewed canonical sequence.

>Q15027|ACAP1
     1  MTVKLDFEEC LKDSPRFRAS IELVEAEVSE LETRLEKLLK LGTGLLESGR HYLAASRAFV
    61  VGICDLARLG PPEPMMAECL EKFTVSLNHK LDSHAELLDA TQHTLQQQIQ TLVKEGLRGF
   121  REARRDFWRG AESLEAALTH NAEVPRRRAQ EAEEAGAALR TARAGYRGRA LDYALQINVI
   181  EDKRKFDIME FVLRLVEAQA THFQQGHEEL SRLSQYRKEL GAQLHQLVLN SAREKRDMEQ
   241  RHVLLKQKEL GGEEPEPSLR EGPGGLVMEG HLFKRASNAF KTWSRRWFTI QSNQLVYQKK
   301  YKDPVTVVVD DLRLCTVKLC PDSERRFCFE VVSTSKSCLL QADSERLLQL WVSAVQSSIA
   361  SAFSQARLDD SPRGPGQGSG HLAIGSAATL GSGGMARGRE PGGVGHVVAQ VQSVDGNAQC
   421  CDCREPAPEW ASINLGVTLC IQCSGIHRSL GVHFSKVRSL TLDSWEPELV KLMCELGNVI
   481  INQIYEARVE AMAVKKPGPS CSRQEKEAWI HAKYVEKKFL TKLPEIRGRR GGRGRPRGQP
   541  PVPPKPSIRP RPGSLRSKPE PPSEDLGSLH PGALLFRASG HPPSLPTMAD ALAHGADVNW
   601  VNGGQDNATP LIQATAANSL LACEFLLQNG ANVNQADSAG RGPLHHATIL GHTGLACLFL
   661  KRGADLGARD SEGRDPLTIA METANADIVT LLRLAKMREA EAAQGQAGDE TYLDIFRDFS
   721  LMASDDPEKL SRRSHDLHTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 93 nTPM
  • small intestine: 41 nTPM
  • bone marrow: 39 nTPM
  • lymph node: 37 nTPM
  • thymus: 24 nTPM
  • tonsil: 21 nTPM

Single-cell type

  • late spermatids: 4,047 nCPM
  • early spermatids: 363 nCPM
  • t-cells: 144 nCPM
  • neutrophils: 109 nCPM
  • nk-cells: 108 nCPM
  • b-cells: 81 nCPM

Immune cell

  • T-reg: 39 nTPM
  • MAIT T-cell: 33 nTPM
  • NK-cell: 33 nTPM
  • memory CD8 T-cell: 32 nTPM
  • memory CD4 T-cell: 32 nTPM
  • eosinophil: 31 nTPM

Brain region

  • thalamus: 1.5 nTPM
  • cerebral cortex: 1.4 nTPM
  • medulla oblongata: 1 nTPM
  • pons: 0.9 nTPM
  • white matter: 0.9 nTPM
  • cerebellum: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.07
gnomAD missense Z
2.3
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACAP1 as an antibody target. Whether an autoantibody or antibody against ACAP1 could matter depends on whether native ACAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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