Seroatlas · Human Serome Atlas

FNBP1L

Formin-binding protein 1-like

Also known as: C1orf39, FBP1L_HUMAN, FLJ20275, TOCA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T0N5
Gene
FNBP1L
Ensembl
ENSG00000137942
Chromosome
1
Canonical length
605 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q5T0N5|FNBP1L
     1  MSWGTELWDQ FDSLDKHTQW GIDFLERYAK FVKERIEIEQ NYAKQLRNLV KKYCPKRSSK
    61  DEEPRFTSCV AFFNILNELN DYAGQREVVA EEMAHRVYGE LMRYAHDLKT ERKMHLQEGR
   121  KAQQYLDMCW KQMDNSKKKF ERECREAEKA QQSYERLDND TNATKADVEK AKQQLNLRTH
   181  MADENKNEYA AQLQNFNGEQ HKHFYVVIPQ IYKQLQEMDE RRTIKLSECY RGFADSERKV
   241  IPIISKCLEG MILAAKSVDE RRDSQMVVDS FKSGFEPPGD FPFEDYSQHI YRTISDGTIS
   301  ASKQESGKMD AKTTVGKAKG KLWLFGKKPK PQSPPLTPTS LFTSSTPNGS QFLTFSIEPV
   361  HYCMNEIKTG KPRIPSFRSL KRGWSVKMGP ALEDFSHLPP EQRRKKLQQR IDELNRELQK
   421  ESDQKDALNK MKDVYEKNPQ MGDPGSLQPK LAETMNNIDR LRMEIHKNEA WLSEVEGKTG
   481  GRGDRRHSSD INHLVTQGRE SPEGSYTDDA NQEVRGPPQQ HGHHNEFDDE FEDDDPLPAI
   541  GHCKAIYPFD GHNEGTLAMK EGEVLYIIEE DKGDGWTRAR RQNGEEGYVP TSYIDVTLEK
   601  NSKGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNBP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 41 nTPM
  • kidney: 34 nTPM
  • breast: 31 nTPM
  • thyroid gland: 30 nTPM
  • adipose tissue: 27 nTPM
  • stomach: 22 nTPM

Single-cell type

  • podocytes: 553 nCPM
  • renal collecting duct intercalated cells: 535 nCPM
  • lacrimal acinar cells: 496 nCPM
  • salivary acinar cells: 473 nCPM
  • prostatic hillock cells: 457 nCPM
  • bergmann glia: 371 nCPM

Immune cell

  • basophil: 7.3 nTPM
  • plasmacytoid DC: 1.5 nTPM
  • eosinophil: 0.7 nTPM
  • naive B-cell: 0.4 nTPM
  • memory B-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM

Brain region

  • basal ganglia: 50 nTPM
  • midbrain: 37 nTPM
  • spinal cord: 30 nTPM
  • hypothalamus: 29 nTPM
  • medulla oblongata: 27 nTPM
  • pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.75
gnomAD missense Z
2.11
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FNBP1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNBP1L as an antibody target. Whether an autoantibody or antibody against FNBP1L could matter depends on whether native FNBP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNBP1L is annotated at the cell surface, where native FNBP1L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FNBP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FNBP1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...