Seroatlas · Human Serome Atlas

SNX1

Sorting nexin-1

Also known as: HsT17379, MGC8664, SNX1_HUMAN, SNX1A, Vps5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13596
Gene
SNX1
Ensembl
ENSG00000028528
Chromosome
15
Canonical length
522 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Endosomes,Lysosomes
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q13596|SNX1
     1  MASGGGGCSA SERLPPPFPG LEPESEGAAG GSEPEAGDSD TEGEDIFTGA AVVSKHQSPK
    61  ITTSLLPINN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVLA KTLISLPPQE
   121  ATNSSKPQPT YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPLFRSKQ
   181  FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA
   241  ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQTLS GAGLLKMFNK ATDAVSKMTI
   301  KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTAQFAKS LAMLGSSEDN
   361  TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW
   421  QDAQATLQKK REAEARLLWA NKPDKLQQAK DEILEWESRV TQYERDFERI STVVRKEVIR
   481  FEKEKSKDFK NHVIKYLETL LYSQQQLAKY WEAFLPEAKA IS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
120 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 120 nTPM
  • spinal cord: 95 nTPM
  • thymus: 74 nTPM
  • adrenal gland: 73 nTPM
  • parathyroid gland: 68 nTPM
  • skeletal muscle: 67 nTPM

Single-cell type

  • myonuclei: 568 nCPM
  • oligodendrocytes: 242 nCPM
  • alveolar cells type 1: 171 nCPM
  • oligodendrocyte progenitor cells: 161 nCPM
  • thymic myoid cells: 158 nCPM
  • neutrophils: 156 nCPM

Immune cell

  • eosinophil: 163 nTPM
  • total PBMC: 156 nTPM
  • classical monocyte: 149 nTPM
  • basophil: 145 nTPM
  • non-classical monocyte: 145 nTPM
  • intermediate monocyte: 143 nTPM

Brain region

  • white matter: 126 nTPM
  • medulla oblongata: 113 nTPM
  • midbrain: 104 nTPM
  • spinal cord: 103 nTPM
  • basal ganglia: 103 nTPM
  • cerebellum: 99 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.93
gnomAD missense Z
0.8
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX1 as an antibody target. Whether an autoantibody or antibody against SNX1 could matter depends on whether native SNX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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