Seroatlas · Human Serome Atlas

ARHGAP42

Rho GTPase-activating protein 42

Also known as: AD031, FLJ32810, GRAF3, RHG42_HUMAN, TMEM133

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NI28
Gene: ARHGAP42
Ensembl: ENSG00000165895
Chromosome: 11
Canonical length: 874 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

874 residues, UniProt reviewed canonical sequence.

>A6NI28|ARHGAP42
     1  MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL RNLSMAVQKF
    61  SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE RRRLIQNAND VLIAPLEKFR
   121  KEQIGAAKDG KKKFDKESEK YYSILEKHLN LSAKKKESHL QEADTQIDRE HQNFYEASLE
   181  YVFKIQEVQE KKKFEFVEPL LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE
   241  STRQEVERLM QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM
   301  SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG IITLQAFSEA
   361  NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK CIQAVETRGI TILGLYRIGG
   421  VNSKVQKLMN TTFSPKSPPD IDIDIELWDN KTITSGLKNY LRCLAEPLMT YKLHKDFIIA
   481  VKSDDQNYRV EAVHALVHKL PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL
   541  MRAQEETVAA MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS
   601  TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS ASCQPREKSG
   661  GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD CQSVASVTSP GDVSPPIDLV
   721  KKEPYGLSGL KRASASSLRS ISAAEGNKSY SGSIQSLTSV GSKETPKASP NPDLPPKMCR
   781  RLRLDTASSN GYQRPGSVVA AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG
   841  AIFSNVYPSV EPGWLKATYE GKTGLVPENY VVFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

retina: 29 nTPM
placenta: 14 nTPM
liver: 9.4 nTPM
stomach: 8.9 nTPM
thymus: 8.7 nTPM
kidney: 8.6 nTPM

Single-cell type

urothelial cells: 853 nCPM
rod photoreceptor cells: 583 nCPM
foveolar cells: 474 nCPM
pericytes: 450 nCPM
transitional alveolar cells: 448 nCPM
respiratory ciliated cells: 393 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
memory B-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

hypothalamus: 14 nTPM
choroid plexus: 14 nTPM
midbrain: 12 nTPM
white matter: 12 nTPM
medulla oblongata: 11 nTPM
spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 2.96

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP42 as an antibody target. Whether an autoantibody or antibody against ARHGAP42 could matter depends on whether native ARHGAP42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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