PSTPIP2
Proline-serine-threonine phosphatase-interacting protein 2
Also known as: PPIP2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H939
- Gene
- PSTPIP2
- Ensembl
- ENSG00000152229
- Chromosome
- 18
- Canonical length
- 334 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
Predicted to be located in cytoskeleton; cytosol; and membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
334 residues, UniProt reviewed canonical sequence.
>Q9H939|PSTPIP2
1 MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS
61 RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE
121 LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS
181 KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ
241 QCVTSDEMYE QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA
301 TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PSTPIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 68 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 68 nTPM
- spleen: 61 nTPM
- skeletal muscle: 31 nTPM
- placenta: 11 nTPM
- lung: 11 nTPM
- appendix: 11 nTPM
Single-cell type
- neutrophils: 1,123 nCPM
- tuft cells: 1,095 nCPM
- neutrophil progenitors: 676 nCPM
- platelets: 411 nCPM
- megakaryocytes: 408 nCPM
- megakaryocyte progenitors: 301 nCPM
Immune cell
- eosinophil: 113 nTPM
- basophil: 77 nTPM
- non-classical monocyte: 37 nTPM
- intermediate monocyte: 35 nTPM
- classical monocyte: 25 nTPM
- myeloid DC: 25 nTPM
Brain region
- medulla oblongata: 3.5 nTPM
- choroid plexus: 3.3 nTPM
- white matter: 2.6 nTPM
- pons: 2.4 nTPM
- hypothalamus: 2.2 nTPM
- midbrain: 2.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.57
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.14
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- FCH domain
- AH/BAR domain superfamily
- F-BAR domain
- Fes/CIP4, and EFC/F-BAR homology domain
- Proline-serine-threonine phosphatase-interacting protein 2, F-BAR domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PSTPIP2 as an antibody target. Whether an autoantibody or antibody against PSTPIP2 could matter depends on whether native PSTPIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PSTPIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PSTPIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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