Seroatlas · Human Serome Atlas

SH3GL3

Endophilin-A3

Also known as: CNSA3, EEN-B2, HsT19371, SH3D2C, SH3G3_HUMAN, SH3P13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99963
Gene
SH3GL3
Ensembl
ENSG00000140600
Chromosome
15
Canonical length
347 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in central nervous system development and signal transduction. Predicted to be located in acrosomal vesicle and early endosome membrane. Predicted to be part of early endosome. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endosome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q99963|SH3GL3
     1  MSVAGLKKQF HKASQLFSEK ISGAEGTKLD DEFLDMERKI DVTNKVVAEI LSKTTEYLQP
    61  NPAYRAKLGM LNTVSKIRGQ VKTTGYPQTE GLLGDCMLKY GKELGEDSTF GNALIEVGES
   121  MKLMAEVKDS LDINVKQTFI DPLQLLQDKD LKEIGHHLKK LEGRRLDYDY KKKRVGKIPD
   181  EEVRQAVEKF EESKELAERS MFNFLENDVE QVSQLAVFIE AALDYHRQST EILQELQSKL
   241  QMRISAASSV PRREYKPRPV KRSSSELNGV STTSVVKTTG SNIPMDQPCC RGLYDFEPEN
   301  QGELGFKEGD IITLTNQIDE NWYEGMIHGE SGFFPINYVE VIVPLPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3GL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 57 nTPM
  • midbrain: 42 nTPM
  • hippocampal formation: 40 nTPM
  • amygdala: 32 nTPM
  • hypothalamus: 29 nTPM
  • cerebral cortex: 28 nTPM

Single-cell type

  • late spermatids: 2,396 nCPM
  • oligodendrocytes: 1,311 nCPM
  • early spermatids: 804 nCPM
  • retinal horizontal cells: 539 nCPM
  • loop of henle epithelial cells: 328 nCPM
  • brain inhibitory neurons: 285 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 127 nTPM
  • basal ganglia: 82 nTPM
  • cerebral cortex: 76 nTPM
  • midbrain: 70 nTPM
  • pons: 66 nTPM
  • hypothalamus: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
1.21
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH3GL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3GL3 as an antibody target. Whether an autoantibody or antibody against SH3GL3 could matter depends on whether native SH3GL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3GL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3GL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SH3GL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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