SH3GLB2
Endophilin-B2
Also known as: KIAA1848, SHLB2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NR46
- Gene
- SH3GLB2
- Ensembl
- ENSG00000148341
- Chromosome
- 9
- Canonical length
- 395 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in membrane organization and postsynaptic neurotransmitter receptor internalization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
395 residues, UniProt reviewed canonical sequence.
>Q9NR46|SH3GLB2
1 MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK NWTEKILRQT
61 EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAD AASELGPTTP YGKTLIKVAE
121 AEKQLGAAER DFIHTASISF LTPLRNFLEG DWKTISKERR LLQNRRLDLD ACKARLKKAK
181 AAEAKATTVP DFQETRPRNY ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE
241 GISSTHVNHL RCLHEFVKSQ TTYYAQCYRH MLDLQKQLGR FPGTFVGTTE PASPPLSSTS
301 PTTAAATMPV VPSVASLAPP GEASLCLEEV APPASGTRKA RVLYDYEAAD SSELALLADE
361 LITVYSLPGM DPDWLIGERG NKKGKVPVTY LELLSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SH3GLB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 142 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 142 nTPM
- amygdala: 118 nTPM
- skin: 113 nTPM
- hippocampal formation: 111 nTPM
- spinal cord: 106 nTPM
- esophagus: 99 nTPM
Single-cell type
- esophageal apical cells: 240 nCPM
- syncytiotrophoblasts: 193 nCPM
- cytotrophoblasts: 156 nCPM
- urothelial cells: 114 nCPM
- oligodendrocytes: 111 nCPM
- prostatic club cells: 109 nCPM
Immune cell
- plasmacytoid DC: 3.7 nTPM
- eosinophil: 3.6 nTPM
- memory B-cell: 3.6 nTPM
- NK-cell: 2.6 nTPM
- non-classical monocyte: 2.6 nTPM
- MAIT T-cell: 2.3 nTPM
Brain region
- cerebral cortex: 130 nTPM
- white matter: 116 nTPM
- basal ganglia: 109 nTPM
- amygdala: 105 nTPM
- hippocampal formation: 105 nTPM
- pons: 96 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.74
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.38
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SH3GLB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SH3GLB2 as an antibody target. Whether an autoantibody or antibody against SH3GLB2 could matter depends on whether native SH3GLB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SH3GLB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SH3GLB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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