Seroatlas · Human Serome Atlas

ARHGEF38

Rho guanine nucleotide exchange factor 38

Also known as: ARH38_HUMAN, FLJ20184

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXL2
Gene: ARHGEF38
Ensembl: ENSG00000236699
Chromosome: 4
Canonical length: 777 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>Q9NXL2|ARHGEF38
     1  MEPKEATGKE NMVTKKKNLA FLRSRLYMLE RRKTDTVVES SVSGDHSGTL RRSQSDRTEY
    61  NQKLQEKMTP QGECSVAETL TPEEEHHMKR MMAKREKIIK ELIQTEKDYL NDLELCVREV
   121  VQPLRNKKTD RLDVDSLFSN IESVHQISAK LLSLLEEATT DVEPAMQVIG EVFLQIKGPL
   181  EDIYKIYCYH HDEAHSILES YEKEEELKEH LSHCIQSLKK IYMQEGKPNL LDMGSLMIKP
   241  IQRVMKYPLL LCELRNSTPP SHPDYRALDD AFAAVKDINV NINELKRRKD LVLKYKKNDE
   301  DESLKDKLSK LNIHSISKKS KRVTNHLKIL TRGESQVKDN TFNREEKLFR ALEKTVRLCV
   361  KNISLCLQHI QDAMPLALQS VMDLQEISYN KDDEMDYSET LSNALNSCHD FASHLQRLIL
   421  TPLSALLSLF PGPHKLIQKR YDKLLDCNSY LQRSTGEESD LAKKEYEALN AQLVEELQAF
   481  NQAARKILLN CLCSFITLLR DLMLVAQQAY STLVPMPLLV SSISEIQNQV LEEIQNLNCV
   541  KENSATFIER KLSFEKKKPV QILPEMPHQT DIHRSKLLST YSAEELYQAK RKCNATQEYD
   601  INLLEGDLVA VIEQKDPLGS TSRWLVDTGN VKGYVYSSFL KPYNPAKMQK VDAENRFCDD
   661  DFENISLFVS SRPASDSVTG TSESSIGDSS SSLSGTCGKF ETNGTDVDSF QEVDEQIFYA
   721  VHAFQARSDH ELSLQEYQRV HILRFCDLSG NKEWWLAEAQ GQKGYVPANY LGKMTYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 7.4 nTPM

Expression across tissuesHPA

Tissue

breast: 7.4 nTPM
pancreas: 6.1 nTPM
prostate: 5.4 nTPM
epididymis: 5.2 nTPM
salivary gland: 4.7 nTPM
rectum: 3.9 nTPM

Single-cell type

tuft cells: 507 nCPM
prostatic glandular cells: 439 nCPM
alveolar cells type 2: 245 nCPM
loop of henle epithelial cells: 229 nCPM
paneth cells: 224 nCPM
renal connecting tubule cells: 221 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
choroid plexus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF38 as an antibody target. Whether an autoantibody or antibody against ARHGEF38 could matter depends on whether native ARHGEF38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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