Seroatlas · Human Serome Atlas

SRGAP2B

SLIT-ROBO Rho GTPase-activating protein 2B

Also known as: SRG2B_HUMAN, SRGAP2P2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DMP2
Gene: SRGAP2B
Ensembl: ENSG00000196369
Chromosome: 1
Canonical length: 458 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Basal body,Cytosol

OverviewNCBI Gene

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>P0DMP2|SRGAP2B
     1  MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE
    61  MDYSRNLEKL AERFLAKTCS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY
   121  LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK
   181  LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT
   241  ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTFLSAELN
   301  LEQSKHEGLD AIENAVENLD ATSDKQRLME MYNNVFCPPM KFEFQPHMGD MASQLCAQQP
   361  VQSELLQRCQ QLQSRLSTLK IENEEVKKTM EATLQTIQDI VTVEDFDVSD CFQYSNSMES
   421  VKSTVSETFM SKPSIAKRRA NQQETEQFYF TVRECYGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRGAP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 56 nTPM
skin: 15 nTPM
spinal cord: 11 nTPM
hippocampal formation: 8.6 nTPM
spleen: 8.6 nTPM
adrenal gland: 7.5 nTPM

Single-cell type

podocytes: 733 nCPM
microglia: 458 nCPM
macrophages: 130 nCPM
cdc: 79 nCPM
monocyte progenitors: 77 nCPM
monocytes: 74 nCPM

Immune cell

non-classical monocyte: 5.1 nTPM
intermediate monocyte: 4.1 nTPM
plasmacytoid DC: 2.8 nTPM
classical monocyte: 2.6 nTPM
neutrophil: 2.2 nTPM
myeloid DC: 2 nTPM

Brain region

cerebellum: 50 nTPM
pons: 21 nTPM
white matter: 18 nTPM
medulla oblongata: 18 nTPM
spinal cord: 17 nTPM
cerebral cortex: 17 nTPM

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRGAP2B as an antibody target. Whether an autoantibody or antibody against SRGAP2B could matter depends on whether native SRGAP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRGAP2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRGAP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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