Seroatlas · Human Serome Atlas

BIN2

Bridging integrator 2

Also known as: BIN2_HUMAN, BRAP-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBW5
Gene: BIN2
Ensembl: ENSG00000110934
Chromosome: 12
Canonical length: 565 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables phospholipid binding activity. Involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Located in phagocytic cup and podosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

565 residues, UniProt reviewed canonical sequence.

>Q9UBW5|BIN2
     1  MAEGKAGGAA GLFAKQVQKK FSRAQEKVLQ KLGKAVETKD ERFEQSASNF YQQQAEGHKL
    61  YKDLKNFLSA VKVMHESSKR VSETLQEIYS SEWDGHEELK AIVWNNDLLW EDYEEKLADQ
   121  AVRTMEIYVA QFSEIKERIA KRGRKLVDYD SARHHLEAVQ NAKKKDEAKT AKAEEEFNKA
   181  QTVFEDLNQE LLEELPILYN SRIGCYVTIF QNISNLRDVF YREMSKLNHN LYEVMSKLEK
   241  QHSNKVFVVK GLSSSSRRSL VISPPVRTAT VSSPLTSPTS PSTLSLKSES ESVSATEDLA
   301  PDAAQGEDNS EIKELLEEEE IEKEGSEASS SEEDEPLPAC NGPAQAQPSP TTERAKSQEE
   361  VLPSSTTPSP GGALSPSGQP SSSATEVVLR TRTASEGSEQ PKKRASIQRT SAPPSRPPPP
   421  RATASPRPSS GNIPSSPTAS GGGSPTSPRA SLGTGTASPR TSLEVSPNPE PPEKPVRTPE
   481  AKENENIHNQ NPEELCTSPT LMTSQVASEP GEAKKMEDKE KDNKLISANS SEGQDQLQVS
   541  MVPENNNLTA PEPQEEVSTS ENPQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 96 nTPM
spleen: 49 nTPM
thymus: 45 nTPM
lymph node: 39 nTPM
tonsil: 34 nTPM
appendix: 31 nTPM

Single-cell type

platelets: 1,233 nCPM
neutrophils: 548 nCPM
megakaryocytes: 532 nCPM
neutrophil progenitors: 390 nCPM
nk-cells: 339 nCPM
extravillous trophoblasts: 293 nCPM

Immune cell

basophil: 666 nTPM
total PBMC: 479 nTPM
non-classical monocyte: 414 nTPM
neutrophil: 381 nTPM
intermediate monocyte: 312 nTPM
gdT-cell: 282 nTPM

Brain region

thalamus: 10 nTPM
white matter: 9.5 nTPM
medulla oblongata: 8.5 nTPM
pons: 7.2 nTPM
midbrain: 5.8 nTPM
spinal cord: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phospholipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Amphiphysin
BAR domain
AH/BAR domain superfamily
BAR domain
Bridging integrator 2, BAR domain
Bridging integrator 2, C-terminal tail
Bridging integrator 2, C-terminal tail

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIN2 as an antibody target. Whether an autoantibody or antibody against BIN2 could matter depends on whether native BIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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