Seroatlas · Human Serome Atlas

BAIAP2L2

BAR/IMD domain-containing adapter protein 2-like 2

Also known as: BI2L2_HUMAN, FLJ22582, pinkbar

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXY1
Gene: BAIAP2L2
Ensembl: ENSG00000128298
Chromosome: 22
Canonical length: 529 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene binds phosphoinositides and promotes the formation of planar or curved membrane structures. The encoded protein is found in RAB13-positive vesicles and at intercellular contacts with the plasma membrane. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q6UXY1|BAIAP2L2
     1  MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV YFSAIQKIGE
    61  RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL LQHMEKNTKL DMQFIKDSRQ
   121  HYELEYRHRA ANLEKCMSEL WRMERKRDKN VREMKESVNR LHAQMQAFVS ESQRAAELEE
   181  KRRYRFLAEK HLLLSNTFLQ FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG
   241  PPYPSGRLTP TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA
   301  SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD VVEVLVPEAQ
   361  NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT SMTSMSPMTP MNPGNELPSR
   421  SYPLRGSHSL DDLLDRPGNS IAPSEYWDGQ SRSRTPSRVP SRAPSPAPPP LPSSRRSSMG
   481  STAVATDVKK LMSSEQYPPQ ELFPRGTNPF ATVKLRPTIT NDRSAPLIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAIAP2L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

duodenum: 93 nTPM
small intestine: 77 nTPM
kidney: 36 nTPM
colon: 35 nTPM
gallbladder: 14 nTPM
rectum: 12 nTPM

Single-cell type

esophageal apical cells: 304 nCPM
enterocytes: 211 nCPM
leydig cells: 112 nCPM
peritubular myoid cells: 92 nCPM
colonocytes: 83 nCPM
goblet cells: 82 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 3.1 nTPM
cerebral cortex: 2.8 nTPM
amygdala: 1.9 nTPM
basal ganglia: 1.9 nTPM
hippocampal formation: 1.9 nTPM
pons: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phospholipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH3 domain
IMD/I-BAR domain
AH/BAR domain superfamily
I-BAR domain containing protein IRSp53/IRTKS/Pinkbar
SH3-like domain superfamily
IRSp53/MIM homology domain
Variant SH3 domain
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, I-BAR domain
Pinkbar, SH3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAIAP2L2 as an antibody target. Whether an autoantibody or antibody against BAIAP2L2 could matter depends on whether native BAIAP2L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAIAP2L2 is annotated at the cell surface, where native BAIAP2L2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BAIAP2L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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