Seroatlas · Human Serome Atlas

SNX7

Sorting nexin-7

Also known as: SNX7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNH6
Gene
SNX7
Ensembl
ENSG00000162627
Chromosome
1
Canonical length
387 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q9UNH6|SNX7
     1  MDMNSFSPMM PTSPLSMINQ IKFEDEPDLK DLFITVDEPE SHVTTIETFI TYRIITKTSR
    61  GEFDSSEFEV RRRYQDFLWL KGKLEEAHPT LIIPPLPEKF IVKGMVERFN DDFIETRRKA
   121  LHKFLNRIAD HPTLTFNEDF KIFLTAQAWE LSSHKKQGPG LLSRMGQTVR AVASSMRGVK
   181  NRPEEFMEMN NFIELFSQKI NLIDKISQRI YKEEREYFDE MKEYGPIHIL WSASEEDLVD
   241  TLKDVASCID RCCKATEKRM SGLSEALLPV VHEYVLYSEM LMGVMKRRDQ IQAELDSKVE
   301  VLTYKKADTD LLPEEIGKLE DKVECANNAL KADWERWKQN MQNDIKLAFT DMAEENIHYY
   361  EQCLATWESF LTSQTNLHLE EASEDKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 32 nTPM
  • colon: 28 nTPM
  • rectum: 28 nTPM
  • smooth muscle: 24 nTPM
  • kidney: 23 nTPM
  • duodenum: 22 nTPM

Single-cell type

  • thymic myoid cells: 194 nCPM
  • sertoli cells: 114 nCPM
  • decidual stromal cells: 87 nCPM
  • oligodendrocyte progenitor cells: 87 nCPM
  • respiratory ciliated cells: 80 nCPM
  • peritubular myoid cells: 71 nCPM

Immune cell

  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • thalamus: 29 nTPM
  • hypothalamus: 23 nTPM
  • midbrain: 21 nTPM
  • medulla oblongata: 18 nTPM
  • white matter: 16 nTPM
  • amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX7 as an antibody target. Whether an autoantibody or antibody against SNX7 could matter depends on whether native SNX7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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