Seroatlas · Human Serome Atlas

PACSIN1

Protein kinase C and casein kinase substrate in neurons protein 1

Also known as: PACN1_HUMAN, SDPI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY11
Gene: PACSIN1
Ensembl: ENSG00000124507
Chromosome: 6
Canonical length: 444 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables phospholipid binding activity. Involved in plasma membrane tubulation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>Q9BY11|PACSIN1
     1  MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA KIEKAYGQQL
    61  TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE VKNNLLNEDL EKVKNWQKDA
   121  YHKQIMGGFK ETKEAEDGFR KAQKPWAKKM KELEAAKKAY HLACKEEKLA MTREMNSKTE
   181  QSVTPEQQKK LQDKVDKCKQ DVQKTQEKYE KVLEDVGKTT PQYMENMEQV FEQCQQFEEK
   241  RLVFLKEVLL DIKRHLNLAE NSSYIHVYRE LEQAIRGADA QEDLRWFRST SGPGMPMNWP
   301  QFEEWNPDLP HTTTKKEKQP KKAEGVALTN ATGAVESTSQ AGDRGSVSSY DRGQPYATEW
   361  SDDESGNPFG GSETNGGANP FEDDSKGVRV RALYDYDGQE QDELSFKAGD ELTKLGEEDE
   421  QGWCRGRLDS GQLGLYPANY VEAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PACSIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 239 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 239 nTPM
amygdala: 166 nTPM
hippocampal formation: 137 nTPM
basal ganglia: 125 nTPM
cerebellum: 117 nTPM
hypothalamus: 84 nTPM

Single-cell type

pdcs: 188 nCPM
rod photoreceptor cells: 175 nCPM
cone photoreceptor cells: 139 nCPM
retinal amacrine cells: 134 nCPM
retinal bipolar cells: 90 nCPM
brain excitatory neurons: 77 nCPM

Immune cell

plasmacytoid DC: 16 nTPM
NK-cell: 3.6 nTPM
memory CD8 T-cell: 0.4 nTPM
MAIT T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

cerebral cortex: 485 nTPM
pons: 297 nTPM
white matter: 294 nTPM
basal ganglia: 274 nTPM
amygdala: 260 nTPM
hippocampal formation: 247 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 2.63
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PACSIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PACSIN1 as an antibody target. Whether an autoantibody or antibody against PACSIN1 could matter depends on whether native PACSIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PACSIN1 is annotated at the cell surface, where native PACSIN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PACSIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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