Seroatlas · Human Serome Atlas

TRIP10

Cdc42-interacting protein 4

Also known as: CIP4, CIP4_HUMAN, HSTP, STOT, STP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15642
Gene
TRIP10
Ensembl
ENSG00000125733
Chromosome
19
Canonical length
601 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in actin cytoskeleton organization and signal transduction. Located in nucleoplasm. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

601 residues, UniProt reviewed canonical sequence.

>Q15642|TRIP10
     1  MDWGTELWDQ FEVLERHTQW GLDLLDRYVK FVKERTEVEQ AYAKQLRSLV KKYLPKRPAK
    61  DDPESKFSQQ QSFVQILQEV NDFAGQRELV AENLSVRVCL ELTKYSQEMK QERKMHFQEG
   121  RRAQQQLENG FKQLENSKRK FERDCREAEK AAQTAERLDQ DINATKADVE KAKQQAHLRS
   181  HMAEESKNEY AAQLQRFNRD QAHFYFSQMP QIFDKLQDMD ERRATRLGAG YGLLSEAELE
   241  VVPIIAKCLE GMKVAANAVD PKNDSHVLIE LHKSGFARPG DVEFEDFSQP MNRAPSDSSL
   301  GTPSDGRPEL RGPGRSRTKR WPFGKKNKPR PPPLSPLGGP VPSALPNGPP SPRSGRDPLA
   361  ILSEISKSVK PRLASFRSLR GSRGTVVTED FSHLPPEQQR KRLQQQLEER SRELQKEVDQ
   421  REALKKMKDV YEKTPQMGDP ASLEPQIAET LSNIERLKLE VQKYEAWLAE AESRVLSNRG
   481  DSLSRHARPP DPPASAPPDS SSNSASQDTK ESSEEPPSEE SQDTPIYTEF DEDFEEEPTS
   541  PIGHCVAIYH FEGSSEGTIS MAEGEDLSLM EEDKGDGWTR VRRKEGGEGY VPTSYLRVTL
   601  N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
340 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 340 nTPM
  • esophagus: 243 nTPM
  • tongue: 166 nTPM
  • vagina: 142 nTPM
  • heart muscle: 117 nTPM
  • cervix: 117 nTPM

Single-cell type

  • esophageal apical cells: 1,828 nCPM
  • esophageal suprabasal cells: 167 nCPM
  • epididymal basal cells: 126 nCPM
  • ocular epithelial cells: 100 nCPM
  • myonuclei: 94 nCPM
  • suprabasal keratinocytes: 90 nCPM

Immune cell

  • plasmacytoid DC: 27 nTPM
  • myeloid DC: 5.2 nTPM
  • NK-cell: 2.5 nTPM
  • naive B-cell: 1.7 nTPM
  • memory B-cell: 1.5 nTPM
  • memory CD8 T-cell: 1.1 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • medulla oblongata: 14 nTPM
  • thalamus: 14 nTPM
  • hypothalamus: 12 nTPM
  • midbrain: 11 nTPM
  • cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
0.56
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIP10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIP10 as an antibody target. Whether an autoantibody or antibody against TRIP10 could matter depends on whether native TRIP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIP10 is annotated at the cell surface, where native TRIP10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRIP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIP10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...