Seroatlas · Human Serome Atlas

CIBAR2

CBY1-interacting BAR domain-containing protein 2

Also known as: CBAR2_HUMAN, FAM92B, FLJ44299

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZTR7
Gene: CIBAR2
Ensembl: ENSG00000153789
Chromosome: 16
Canonical length: 304 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to be involved in cilium assembly. Predicted to be located in cell projection; centriole; and cytoplasm. Predicted to be active in ciliary basal body and ciliary transition zone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q6ZTR7|CIBAR2
     1  MNIVFSRDSQ VRVMENTVAN TEKYFGQFCS LLAAYTRKTA RLRDKADQLV KQLIDFANSE
    61  NPELRATMRG FAEDLAKVQD YRQAQVERLE TKVVNPLKLY GAQIKQTRAE IKKFKHVQNH
   121  EIKQLEKLEK LRQKSPSDQQ MIGQAETRVQ RAAVDSSRTT LQLEETVDGF QRQKLKDLQK
   181  FFCDFVTIEM VFHAKAVEVY SSAFQTLEKY DLERDLLDFR AKMQGVYGHY DTRLLANTSP
   241  PPSVLQSLAS QGTLQVQLSR ANEDPEHPHA NHGRFSLCEW VVKGQPAHCV CGQGGHLMLP
   301  GHSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIBAR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 80 nTPM
choroid plexus: 33 nTPM
pituitary gland: 16 nTPM
lung: 10 nTPM
hypothalamus: 9 nTPM
hippocampal formation: 5 nTPM

Single-cell type

respiratory ciliated cells: 620 nCPM
fallopian tube ciliated cells: 442 nCPM
endometrial ciliated cells: 193 nCPM
epididymal efferent duct ciliated cells: 147 nCPM
ependymal cells: 85 nCPM
plasma cells: 54 nCPM

Immune cell

NK-cell: 0.5 nTPM
memory B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

midbrain: 26 nTPM
choroid plexus: 26 nTPM
medulla oblongata: 21 nTPM
spinal cord: 14 nTPM
hypothalamus: 13 nTPM
pons: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cilium assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIBAR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CBY1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIBAR2 as an antibody target. Whether an autoantibody or antibody against CIBAR2 could matter depends on whether native CIBAR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIBAR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIBAR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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