Seroatlas · Human Serome Atlas

SNX4

Sorting nexin-4

Also known as: ATG24B, SNX4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95219
Gene: SNX4
Ensembl: ENSG00000114520
Chromosome: 3
Canonical length: 450 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>O95219|SNX4
     1  MEQAPPDPER QLQPAPLEPL GSPDAGLGAA VGKEAEGAGE ESSGVDTMTH NNFWLKKIEI
    61  SVSEAEKRTG RNAMNMQETY TAYLIETRSV EHTDGQSVLT DSLWRRYSEF ELLRSYLLVY
   121  YPHIVVPPLP EKRAEFVWHK LSADNMDPDF VERRRIGLEN FLLRIASHPI LCRDKIFYLF
   181  LTQEGNWKET VNETGFQLKA DSRLKALNAT FRVKNPDKRF TDLKHYSDEL QSVISHLLRV
   241  RARVADRLYG VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
   301  ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELVTGTV RTFSLKGMTT
   361  KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV KNAWADIERF KEQKNRDLKE
   421  ALISYAVMQI SMCKKGIQVW TNAKECFSKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

liver: 53 nTPM
kidney: 50 nTPM
thyroid gland: 42 nTPM
duodenum: 34 nTPM
small intestine: 32 nTPM
placenta: 30 nTPM

Single-cell type

cytotrophoblasts: 136 nCPM
myonuclei: 129 nCPM
distal convoluted tubule cells: 124 nCPM
thyrotrophs: 119 nCPM
hepatocytes: 115 nCPM
proximal tubule cells: 113 nCPM

Immune cell

eosinophil: 26 nTPM
non-classical monocyte: 19 nTPM
intermediate monocyte: 19 nTPM
myeloid DC: 18 nTPM
NK-cell: 18 nTPM
plasmacytoid DC: 16 nTPM

Brain region

white matter: 18 nTPM
choroid plexus: 15 nTPM
hypothalamus: 15 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 14 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Phox homology
AH/BAR domain superfamily
PX domain superfamily
PX domain
Sorting nexin-4
Sorting nexin 4, PX domain
Sorting nexin-4, BAR domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX4 as an antibody target. Whether an autoantibody or antibody against SNX4 could matter depends on whether native SNX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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