Seroatlas · Human Serome Atlas

BIN3

Bridging integrator 3

Also known as: BIN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQY0
Gene: BIN3
Ensembl: ENSG00000147439
Chromosome: 8
Canonical length: 253 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q9NQY0|BIN3
     1  MSWIPFKIGQ PKKQIVPKTV ERDFEREYGK LQQLEEQTRR LQKDMKKSTD ADLAMSKSAV
    61  KISLDLLSNP LCEQDQDLLN MVTALDTAMK RMDAFNQEKV NQIQKTVIEP LKKFGSVFPS
   121  LNMAVKRREQ ALQDYRRLQA KVEKYEEKEK TGPVLAKLHQ AREELRPVRE DFEAKNRQLL
   181  EEMPRFYGSR LDYFQPSFES LIRAQVVYYS EMHKIFGDLS HQLDQPGHSD EQRERENEAK
   241  LSELRALSIV ADD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 41 nTPM
choroid plexus: 34 nTPM
adrenal gland: 31 nTPM
adipose tissue: 19 nTPM
breast: 19 nTPM
kidney: 18 nTPM

Single-cell type

neutrophils: 362 nCPM
breast myoepithelial cells: 198 nCPM
neutrophil progenitors: 186 nCPM
adrenal cortex cells: 163 nCPM
müller glia: 158 nCPM
schwann cells: 142 nCPM

Immune cell

neutrophil: 95 nTPM
eosinophil: 82 nTPM
basophil: 67 nTPM
T-reg: 47 nTPM
total PBMC: 42 nTPM
NK-cell: 39 nTPM

Brain region

choroid plexus: 11 nTPM
hippocampal formation: 9.5 nTPM
cerebral cortex: 9 nTPM
medulla oblongata: 8.9 nTPM
white matter: 8.2 nTPM
hypothalamus: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytoskeletal anchor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

BAR domain
AH/BAR domain superfamily
BAR domain
Bridging integrator 3, BAR domain
Bridging integrator 3/RVS161-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DNMBP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIN3 as an antibody target. Whether an autoantibody or antibody against BIN3 could matter depends on whether native BIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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