Seroatlas · Human Serome Atlas

PACSIN2

Protein kinase C and casein kinase substrate in neurons protein 2

Also known as: PACN2_HUMAN, SDPII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNF0
Gene
PACSIN2
Ensembl
ENSG00000100266
Chromosome
22
Canonical length
486 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Vesicles,Plasma membrane,Primary cilium,Centriolar satellite
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>Q9UNF0|PACSIN2
     1  MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR IEKAYAQQLT
    61  EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV KASLMNDDFE KIKNWQKEAF
   121  HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVEAAKKAHH AACKEEKLAI SREANSKADP
   181  SLNPEQLKKL QDKIEKCKQD VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR
   241  LRFFREVLLE VQKHLDLSNV AGYKAIYHDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ
   301  FEEWSADLNR TLSRREKKKA TDGVTLTGIN QTGDQSLPSK PSSTLNVPSN PAQSAQSQSS
   361  YNPFEDEDDT GSTVSEKDDT KAKNVSSYEK TQSYPTDWSD DESNNPFSST DANGDSNPFD
   421  DDATSGTEVR VRALYDYEGQ EHDELSFKAG DELTKMEDED EQGWCKGRLD NGQVGLYPAN
   481  YVEAIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PACSIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
156 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 156 nTPM
  • blood vessel: 104 nTPM
  • adrenal gland: 70 nTPM
  • colon: 58 nTPM
  • heart muscle: 53 nTPM
  • stomach: 49 nTPM

Single-cell type

  • neutrophils: 1,361 nCPM
  • alveolar cells type 2: 578 nCPM
  • pancreatic acinar cells: 525 nCPM
  • alveolar cells type 1: 481 nCPM
  • endometrial luminal cells: 479 nCPM
  • transitional alveolar cells: 450 nCPM

Immune cell

  • neutrophil: 96 nTPM
  • eosinophil: 48 nTPM
  • non-classical monocyte: 34 nTPM
  • intermediate monocyte: 32 nTPM
  • basophil: 26 nTPM
  • myeloid DC: 22 nTPM

Brain region

  • pons: 74 nTPM
  • medulla oblongata: 74 nTPM
  • hypothalamus: 71 nTPM
  • midbrain: 66 nTPM
  • cerebellum: 61 nTPM
  • thalamus: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.21
gnomAD missense Z
1.3
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PACSIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PACSIN2 as an antibody target. Whether an autoantibody or antibody against PACSIN2 could matter depends on whether native PACSIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PACSIN2 is annotated at the cell surface, where native PACSIN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PACSIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PACSIN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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