Seroatlas · Human Serome Atlas

CIBAR1

CBY1-interacting BAR domain-containing protein 1

Also known as: BARMR1, CBAR1_HUMAN, FAM92A, FAM92A1, FLJ38979

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1XBS5
Gene: CIBAR1
Ensembl: ENSG00000188343
Chromosome: 8
Canonical length: 289 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Mitochondria
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables phospholipid binding activity. Involved in several processes, including inner mitochondrial membrane organization; limb morphogenesis; and membrane tubulation. Located in several cellular components, including centriole; ciliary base; and mitochondrial crista. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>A1XBS5|CIBAR1
     1  MMRRTLENRN AQTKQLQTAV SNVEKHFGEL CQIFAAYVRK TARLRDKADL LVNEINAYAA
    61  TETPHLKLGL MNFADEFAKL QDYRQAEVER LEAKVVEPLK TYGTIVKMKR DDLKATLTAR
   121  NREAKQLTQL ERTRQRNPSD RHVISQAETE LQRAAMDASR TSRHLEETIN NFERQKMKDI
   181  KTIFSEFITI EMLFHGKALE VYTAAYQNIQ NIDEDEDLEV FRNSLYAPDY SSRLDIVRAN
   241  SKSPLQRSLS AKCVSGTGQV STCRLRKDQQ AEDDEDDELD VTEEENFLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIBAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 102 nTPM

Expression across tissuesHPA

Tissue

testis: 102 nTPM
cerebral cortex: 30 nTPM
epididymis: 25 nTPM
choroid plexus: 23 nTPM
adrenal gland: 22 nTPM
heart muscle: 22 nTPM

Single-cell type

early spermatids: 1,493 nCPM
late primary spermatocytes: 1000 nCPM
late spermatids: 952 nCPM
cardiomyocytes: 253 nCPM
undifferentiated spermatogonia: 108 nCPM
oocytes: 97 nCPM

Immune cell

myeloid DC: 3.3 nTPM
classical monocyte: 2 nTPM
intermediate monocyte: 1.3 nTPM
NK-cell: 1.2 nTPM
T-reg: 0.7 nTPM
total PBMC: 0.6 nTPM

Brain region

choroid plexus: 50 nTPM
cerebral cortex: 41 nTPM
hippocampal formation: 38 nTPM
basal ganglia: 38 nTPM
cerebellum: 37 nTPM
hypothalamus: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CIBAR1.

Disease | AllUniProt

Conditions CIBAR1 is implicated in, by any mechanism.

Polydactyly, postaxial, A9 (PAPA9) MIM:618219

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Polydactyly, postaxial, type A9
Postaxial polydactyly type A

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phospholipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIBAR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIBAR1 as an antibody target. Whether an autoantibody or antibody against CIBAR1 could matter depends on whether native CIBAR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIBAR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIBAR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...