Seroatlas · Human Serome Atlas

NOSTRIN

Nostrin

Also known as: MGC20702, NOSTN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVI9
Gene: NOSTRIN
Ensembl: ENSG00000163072
Chromosome: 2
Canonical length: 506 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol
Quaternary structure: Homotrimer

OverviewNCBI Gene

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>Q8IVI9|NOSTRIN
     1  MRDPLTDCPY NKVYKNLKEF SQNGENFCKQ VTSVLQQRAN LEISYAKGLQ KLASKLSKAL
    61  QNTRKSCVSS AWAWASEGMK STADLHQKLG KAIELEAIKP TYQVLNVQEK KRKSLDNEVE
   121  KTANLVISNW NQQIKAKKKL MVSTKKHEAL FQLVESSKQS MTEKEKRKLL NKLTKSTEKL
   181  EKEDENYYQK NMAGYSTRLK WENTLENCYQ SILELEKERI QLLCNNLNQY SQHISLFGQT
   241  LTTCHTQIHC AISKIDIEKD IQAVMEETAI LSTENKSEFL LTDYFEEDPN SAMDKERRKS
   301  LLKPKLLRLQ RDIEKASKDK EGLERMLKTY SSTSSFSDAK SQKDTAALMD ENNLKLDLLE
   361  ANSYKLSSML AELEQRPQPS HPCSNSIFRW REKEHTHSYV KISRPFLMKR LENIVSKASS
   421  GGQSNPGSST PAPGAAQLSS RLCKALYSFQ ARQDDELNLE KGDIVIIHEK KEGGWWFGSL
   481  NGKKGHFPAA YVEELPSNAG NTATKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOSTRIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 46 nTPM
adipose tissue: 30 nTPM
breast: 30 nTPM
lung: 29 nTPM
kidney: 27 nTPM
placenta: 24 nTPM

Single-cell type

vascular endothelial cells: 242 nCPM
sertoli cells: 144 nCPM
salivary acinar cells: 137 nCPM
breast lactating cells: 130 nCPM
enterocytes: 106 nCPM
late spermatids: 78 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 8.7 nTPM
medulla oblongata: 8.4 nTPM
pons: 8.3 nTPM
amygdala: 7.3 nTPM
midbrain: 7 nTPM
basal ganglia: 6.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NOSTRIN.

Disease | ImmuneIEDB

Conditions an epitope on NOSTRIN was assayed in.

berylliosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOSTRIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOSTRIN as an antibody target. Whether an autoantibody or antibody against NOSTRIN could matter depends on whether native NOSTRIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOSTRIN is annotated at the cell surface, where native NOSTRIN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NOSTRIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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