Seroatlas · Human Serome Atlas

SNX30

Sorting nexin-30

Also known as: ATG24A, SNX30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VWJ9
Gene: SNX30
Ensembl: ENSG00000148158
Chromosome: 9
Canonical length: 437 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. Involved in positive regulation of autophagosome assembly and protein transport. Is active in early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q5VWJ9|SNX30
     1  MAGGPPKALP STGPHSLRDM PHPLAGSSSE EAVGGDSTPS PDLLMARSFG DKDLILPNGG
    61  TPAGTSSPAS SSSLLNRLQL DDDIDGETRD LFVIVDDPKK HVCTMETYIT YRITTKSTRV
   121  EFDLPEYSVR RRYQDFDWLR SKLEESQPTH LIPPLPEKFV VKGVVDRFSE EFVETRRKAL
   181  DKFLKRITDH PVLSFNEHFN IFLTAKDLNA YKKQGIALLT RMGESVKHVT GGYKLRTRPL
   241  EFAAIGDYLD TFALKLGTID RIAQRIIKEE IEYLVELREY GPVYSTWSAL EGELAEPLEG
   301  VSACIGNCST ALEELTDDMT EDFLPVLREY ILYSDSMKSV LKKRDQVQAE YEAKLEAVAL
   361  RKEDRPKVPA DVEKCQDRME CFNADLKADM ERWQNNKRQD FRQLLMGMAD KNIQYYEKCL
   421  MAWESIIPLL QEKQEAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

lung: 20 nTPM
kidney: 20 nTPM
spinal cord: 14 nTPM
cerebral cortex: 11 nTPM
cerebellum: 11 nTPM
testis: 11 nTPM

Single-cell type

alveolar cells type 2: 321 nCPM
proximal tubule cells: 267 nCPM
transitional alveolar cells: 174 nCPM
oligodendrocytes: 155 nCPM
somatotrophs: 118 nCPM
cdc: 113 nCPM

Immune cell

classical monocyte: 2 nTPM
myeloid DC: 1.6 nTPM
non-classical monocyte: 0.8 nTPM
intermediate monocyte: 0.7 nTPM
total PBMC: 0.7 nTPM
eosinophil: 0.6 nTPM

Brain region

white matter: 65 nTPM
basal ganglia: 48 nTPM
thalamus: 47 nTPM
medulla oblongata: 45 nTPM
cerebral cortex: 42 nTPM
hypothalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.59
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SNX4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX30 as an antibody target. Whether an autoantibody or antibody against SNX30 could matter depends on whether native SNX30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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