Seroatlas · Human Serome Atlas

SNX2

Sorting nexin-2

Also known as: SNX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60749
Gene
SNX2
Ensembl
ENSG00000205302
Chromosome
5
Canonical length
519 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endosomes,Lysosomes
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>O60749|SNX2
     1  MAAEREPPPL GDGKPTDFED LEDGEDLFTS TVSTLESSPS SPEPASLPAE DISANSNGPK
    61  PTEVVLDDDR EDLFAEATEE VSLDSPEREP ILSSEPSPAV TPVTPTTLIA PRIESKSMSA
   121  PVIFDRSREE IEEEANGDIF DIEIGVSDPE KVGDGMNAYM AYRVTTKTSL SMFSKSEFSV
   181  KRRFSDFLGL HSKLASKYLH VGYIVPPAPE KSIVGMTKVK VGKEDSSSTE FVEKRRAALE
   241  RYLQRTVKHP TLLQDPDLRQ FLESSELPRA VNTQALSGAG ILRMVNKAAD AVNKMTIKMN
   301  ESDAWFEEKQ QQFENLDQQL RKLHVSVEAL VCHRKELSAN TAAFAKSAAM LGNSEDHTAL
   361  SRALSQLAEV EEKIDQLHQE QAFADFYMFS ELLSDYIRLI AAVKGVFDHR MKCWQKWEDA
   421  QITLLKKREA EAKMMVANKP DKIQQAKNEI REWEAKVQQG ERDFEQISKT IRKEVGRFEK
   481  ERVKDFKTVI IKYLESLVQT QQQLIKYWEA FLPEAKAIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 25 nTPM
  • thyroid gland: 25 nTPM
  • tonsil: 23 nTPM
  • spleen: 20 nTPM
  • kidney: 19 nTPM
  • placenta: 18 nTPM

Single-cell type

  • hofbauer cells: 683 nCPM
  • extravillous trophoblasts: 430 nCPM
  • b-cells: 391 nCPM
  • migrating cytotrophoblasts: 380 nCPM
  • kupffer cells: 256 nCPM
  • macrophages: 234 nCPM

Immune cell

  • memory B-cell: 291 nTPM
  • naive B-cell: 290 nTPM
  • intermediate monocyte: 89 nTPM
  • non-classical monocyte: 87 nTPM
  • classical monocyte: 78 nTPM
  • basophil: 78 nTPM

Brain region

  • cerebellum: 20 nTPM
  • white matter: 18 nTPM
  • midbrain: 16 nTPM
  • hypothalamus: 15 nTPM
  • spinal cord: 15 nTPM
  • medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
0.6
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX2 as an antibody target. Whether an autoantibody or antibody against SNX2 could matter depends on whether native SNX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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