Seroatlas · Human Serome Atlas

SH3BP1

SH3 domain-binding protein 1

Also known as: 3BP1_HUMAN, ARHGAP43

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y3L3
Gene
SH3BP1
Ensembl
ENSG00000100092
Chromosome
22
Canonical length
701 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

701 residues, UniProt reviewed canonical sequence.

>Q9Y3L3|SH3BP1
     1  MMKRQLHRMR QLAQTGSLGR TPETAEFLGE DLLQVEQRLE PAKRAAHNIH KRLQACLQGQ
    61  SGADMDKRVK KLPLMALSTT MAESFKELDP DSSMGKALEM SCAIQNQLAR ILAEFEMTLE
   121  RDVLQPLSRL SEEELPAILK HKKSLQKLVS DWNTLKSRLS QATKNSGSSQ GLGGSPGSHS
   181  HTTMANKVET LKEEEEELKR KVEQCRDEYL ADLYHFVTKE DSYANYFIRL LEIQADYHRR
   241  SLSSLDTALA ELRENHGQAD HSPSMTATHF PRVYGVSLAT HLQELGREIA LPIEACVMML
   301  LSEGMKEEGL FRLAAGASVL KRLKQTMASD PHSLEEFCSD PHAVAGALKS YLRELPEPLM
   361  TFDLYDDWMR AASLKEPGAR LQALQEVCSR LPPENLSNLR YLMKFLARLA EEQEVNKMTP
   421  SNIAIVLGPN LLWPPEKEGD QAQLDAASVS SIQVVGVVEA LIQSADTLFP GDINFNVSGL
   481  FSAVTLQDTV SDRLASEELP STAVPTPATT PAPAPAPAPA PAPALASAAT KERTESEVPP
   541  RPASPKVTRS PPETAAPVED MARRTKRPAP ARPTMPPPQV SGSRSSPPAP PLPPGSGSPG
   601  TPQALPRRLV GSSLRAPTVP PPLPPTPPQP ARRQSRRSPA SPSPASPGPA SPSPVSLSNP
   661  AQVDLGAATA EGGAPEAISG VPTPPAIPPQ PRPRSLASET N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 39 nTPM
  • skin: 28 nTPM
  • spleen: 28 nTPM
  • vagina: 22 nTPM
  • small intestine: 22 nTPM
  • colon: 20 nTPM

Single-cell type

  • microglia: 35 nCPM
  • oligodendrocyte progenitor cells: 7 nCPM
  • megakaryocytes: 6.2 nCPM
  • monocytes: 5.5 nCPM
  • nk-cells: 4.9 nCPM
  • brain excitatory neurons: 4.1 nCPM

Immune cell

  • eosinophil: 4.7 nTPM
  • non-classical monocyte: 3.7 nTPM
  • basophil: 1.9 nTPM
  • intermediate monocyte: 1.7 nTPM
  • classical monocyte: 1.4 nTPM
  • naive CD8 T-cell: 1.4 nTPM

Brain region

  • cerebral cortex: 9.9 nTPM
  • medulla oblongata: 9.6 nTPM
  • white matter: 9.1 nTPM
  • spinal cord: 7.3 nTPM
  • thalamus: 7.2 nTPM
  • hypothalamus: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.01
gnomAD missense Z
1.58
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH3BP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3BP1 as an antibody target. Whether an autoantibody or antibody against SH3BP1 could matter depends on whether native SH3BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3BP1 is annotated at the cell surface, where native SH3BP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SH3BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SH3BP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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