Seroatlas · Human Serome Atlas

SRGAP3

SLIT-ROBO Rho GTPase-activating protein 3

Also known as: ARHGAP14, KIAA0411, MEGAP, SRGAP2, SRGP3_HUMAN, WRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43295
Gene: SRGAP3
Ensembl: ENSG00000196220
Chromosome: 3
Canonical length: 1099 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Centrosome,Basal body,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of cell migration and regulation of postsynapse assembly. Is active in postsynapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1099 residues, UniProt reviewed canonical sequence.

>O43295|SRGAP3
     1  MSSQTKFKKD KEIIAEYEAQ IKEIRTQLVE QFKCLEQQSE SRLQLLQDLQ EFFRRKAEIE
    61  LEYSRSLEKL AERFSSKIRS SREHQFKKDQ YLLSPVNCWY LVLHQTRRES RDHATLNDIF
   121  MNNVIVRLSQ ISEDVIRLFK KSKEIGLQMH EELLKVTNEL YTVMKTYHMY HAESISAESK
   181  LKEAEKQEEK QFNKSGDLSM NLLRHEDRPQ RRSSVKKIEK MKEKRQAKYS ENKLKCTKAR
   241  NDYLLNLAAT NAAISKYYIH DVSDLIDCCD LGFHASLART FRTYLSAEYN LETSRHEGLD
   301  VIENAVDNLD SRSDKHTVMD MCNQVFCPPL KFEFQPHMGD EVCQVSAQQP VQTELLMRYH
   361  QLQSRLATLK IENEEVRKTL DATMQTLQDM LTVEDFDVSD AFQHSRSTES VKSAASETYM
   421  SKINIAKRRA NQQETEMFYF TKFKEYVNGS NLITKLQAKH DLLKQTLGEG ERAECGTTRP
   481  PCLPPKPQKM RRPRPLSVYS HKLFNGSMEA FIKDSGQAIP LVVESCIRYI NLYGLQQQGI
   541  FRVPGSQVEV NDIKNSFERG EDPLVDDQNE RDINSVAGVL KLYFRGLENP LFPKERFQDL
   601  ISTIKLENPA ERVHQIQQIL VTLPRVVIVV MRYLFAFLNH LSQYSDENMM DPYNLAICFG
   661  PTLMHIPDGQ DPVSCQAHIN EVIKTIIIHH EAIFPSPREL EGPVYEKCMA GGEEYCDSPH
   721  SEPGAIDEVD HDNGTEPHTS DEEVEQIEAI AKFDYMGRSP RELSFKKGAS LLLYHRASED
   781  WWEGRHNGVD GLIPHQYIVV QDMDDAFSDS LSQKADSEAS SGPLLDDKAS SKNDLQSPTE
   841  HISDYGFGGV MGRVRLRSDG AAIPRRRSGG DTHSPPRGLG PSIDTPPRAA ACPSSPHKIP
   901  LTRGRIESPE KRRMATFGSA GSINYPDKKA LSEGHSMRST CGSTRHSSLG DHKSLEAEAL
   961  AEDIEKTMST ALHELRELER QNTVKQAPDV VLDTLEPLKN PPGPVSSEPA SPLHTIVIRD
  1021  PDAAMRRSSS SSTEMMTTFK PALSARLAGA QLRPPPMRPV RPVVQHRSSS SSSSGVGSPA
  1081  VTPTEKMFPN SSADKSGTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRGAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 35 nTPM
cerebral cortex: 18 nTPM
retina: 14 nTPM
hypothalamus: 12 nTPM
hippocampal formation: 11 nTPM
fallopian tube: 10 nTPM

Single-cell type

retinal amacrine cells: 897 nCPM
prostatic hillock cells: 691 nCPM
ependymal cells: 490 nCPM
renal collecting duct principal cells: 462 nCPM
salivary duct cells: 450 nCPM
endometrial ciliated cells: 439 nCPM

Immune cell

eosinophil: 0.3 nTPM
myeloid DC: 0.2 nTPM
NK-cell: 0.2 nTPM
T-reg: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 62 nTPM
cerebral cortex: 55 nTPM
hippocampal formation: 51 nTPM
basal ganglia: 49 nTPM
amygdala: 46 nTPM
hypothalamus: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRGAP3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 197 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Moyamoya angiopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 2.11
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Rho GTPase-activating protein domain
FCH domain
SH3 domain
Rho GTPase activation protein
AH/BAR domain superfamily
F-BAR domain
srGAP1/2/3, SH3 domain
SH3-like domain superfamily
SLIT-ROBO Rho GTPase-activating
SH3 domain
Fes/CIP4, and EFC/F-BAR homology domain
RhoGAP domain
Slit-Robo GTPase Activating Protein 3, F-BAR domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRGAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRGAP3 as an antibody target. Whether an autoantibody or antibody against SRGAP3 could matter depends on whether native SRGAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRGAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRGAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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