Seroatlas · Human Serome Atlas

SRGAP1

SLIT-ROBO Rho GTPase-activating protein 1

Also known as: ARHGAP13, KIAA1304, SRGP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6B7
Gene: SRGAP1
Ensembl: ENSG00000196935
Chromosome: 12
Canonical length: 1085 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Centrosome,Basal body,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

1085 residues, UniProt reviewed canonical sequence.

>Q7Z6B7|SRGAP1
     1  MSTPSRFKKD KEIIAEYESQ VKEIRAQLVE QQKCLEQQTE MRVQLLQDLQ DFFRKKAEIE
    61  TEYSRNLEKL AERFMAKTRS TKDHQQYKKD QNLLSPVNCW YLLLNQVRRE SKDHATLSDI
   121  YLNNVIMRFM QISEDSTRMF KKSKEIAFQL HEDLMKVLNE LYTVMKTYHM YHAESISAES
   181  KLKEAEKQEE KQIGRSGDPV FHIRLEERHQ RRSSVKKIEK MKEKRQAKYS ENKLKSIKAR
   241  NEYLLTLEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTYLSAEYN LETSRHEGLD
   301  IIENAVDNLE PRSDKQRFME MYPAAFCPPM KFEFQSHMGD EVCQVSAQQP VQAELMLRYQ
   361  QLQSRLATLK IENEEVKKTT EATLQTIQDM VTIEDYDVSE CFQHSRSTES VKSTVSETYL
   421  SKPSIAKRRA NQQETEQFYF MKLREYLEGS NLITKLQAKH DLLQRTLGEG HRAEYMTTRP
   481  PNVPPKPQKH RKSRPRSQYN TKLFNGDLET FVKDSGQVIP LIVESCIRFI NLYGLQHQGI
   541  FRVSGSQVEV NDIKNSFERG ENPLADDQSN HDINSVAGVL KLYFRGLENP LFPKERFNDL
   601  ISCIRIDNLY ERALHIRKLL LTLPRSVLIV MRYLFAFLNH LSQYSDENMM DPYNLAICFG
   661  PTLMPVPEIQ DQVSCQAHVN EIIKTIIIHH ETIFPDAKEL DGPVYEKCMA GDDYCDSPYS
   721  EHGTLEEVDQ DAGTEPHTSE DECEPIEAIA KFDYVGRSAR ELSFKKGASL LLYHRASEDW
   781  WEGRHNGIDG LVPHQYIVVQ DMDDTFSDTL SQKADSEASS GPVTEDKSSS KDMNSPTDRH
   841  PDGYLARQRK RGEPPPPVRR PGRTSDGHCP LHPPHALSNS SVDLGSPSLA SHPRGLLQNR
   901  GLNNDSPERR RRPGHGSLTN ISRHDSLKKI DSPPIRRSTS SGQYTGFNDH KPLDPETIAQ
   961  DIEETMNTAL NELRELERQS TAKHAPDVVL DTLEQVKNSP TPATSTESLS PLHNVALRSS
  1021  EPQIRRSTSS SSDTMSTFKP MVAPRMGVQL KPPALRPKPA VLPKTNPTIG PAPPPQGPTD
  1081  KSCTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRGAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 5.9 nTPM

Expression across tissuesHPA

Tissue

lung: 5.9 nTPM
parathyroid gland: 5.5 nTPM
retina: 5.1 nTPM
ovary: 4.5 nTPM
pancreas: 4.5 nTPM
endometrium: 4.1 nTPM

Single-cell type

podocytes: 1,388 nCPM
bergmann glia: 633 nCPM
macrophages: 497 nCPM
salivary acinar cells: 468 nCPM
microglia: 412 nCPM
monocytes: 404 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

medulla oblongata: 29 nTPM
midbrain: 29 nTPM
thalamus: 26 nTPM
basal ganglia: 22 nTPM
cerebellum: 21 nTPM
hypothalamus: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRGAP1.

Disease | AllUniProt

Conditions SRGAP1 is implicated in, by any mechanism.

Thyroid cancer, non-medullary, 2 (NMTC2) MIM:188470

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 181 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Thyroid cancer, nonmedullary, 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 1
gnomAD missense Z: 2.21
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Rho GTPase-activating protein domain
FCH domain
SH3 domain
Rho GTPase activation protein
AH/BAR domain superfamily
F-BAR domain
srGAP1/2/3, SH3 domain
SH3-like domain superfamily
SLIT-ROBO Rho GTPase-activating
SH3 domain
Fes/CIP4, and EFC/F-BAR homology domain
RhoGAP domain
SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRGAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRGAP1 as an antibody target. Whether an autoantibody or antibody against SRGAP1 could matter depends on whether native SRGAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRGAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRGAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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