Seroatlas · Human Serome Atlas

ARHGAP10

Rho GTPase-activating protein 10

Also known as: FLJ20896, FLJ41791, GRAF2, RHG10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A1A4S6
Gene
ARHGAP10
Ensembl
ENSG00000071205
Chromosome
4
Canonical length
786 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Located in cytosol and endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

786 residues, UniProt reviewed canonical sequence.

>A1A4S6|ARHGAP10
     1  MGLQPLEFSD CYLDSPWFRE RIRAHEAELE RTNKFIKELI KDGKNLIAAT KSLSVAQRKF
    61  AHSLRDFKFE FIGDAVTDDE RCIDASLREF SNFLKNLEEQ REIMALSVTE TLIKPLEKFR
   121  KEQLGAVKEE KKKFDKETEK NYSLIDKHLN LSAKKKDSHL QEADIQVEQN RQHFYELSLE
   181  YVCKLQEIQE RKKFEFVEPM LSFFQGMFTF YHQGHELAKD FNHYKMELQI NIQNTRNRFE
   241  GTRSEVEELM NKIRQNPKDH KRASQFTAEG YLYVQEKRPA PFGSSWVKHY CMYRKAAKKF
   301  NMIPFEHRSG GKLGDGEVFF LKECTKRHTD SIDRRFCFDI EAADRPGVSL TMQAFSEEER
   361  KQWLEALGGK EALSHSFNTA IIPRPEGNAQ LDKMGFTIIR KCISAVETRG INDQGLYRVV
   421  GVSSKVQRLL SMLMDVKTCN EVDLENSADW EVKTITSALK QYLRSLPEPL MTYELHGDFI
   481  VPAKSGSPES RVNAIHFLVH KLPEKNKEML DILVKHLTNV SNHSKQNLMT VANLGVVFGP
   541  TLMRPQEETV AALMDLKFQN IVVEILIENH EKIFRTPPDT TFPEPTCLSA SPPNAPPRQS
   601  KRQGQRTKRP VAVYNLCLEL EDGDNPYPSK EDTPTSSLDS LSSPSPVTTA VPGPPGPDKN
   661  HLLADGGSFG DWASTIPGQT RSSMVQWLNP QSPTTTSSNS AVTPLSPGSS PFPFSPPATV
   721  ADKPPESIRS RKARAVYPCE AEHSSELSFE IGAIFEDVQT SREPGWLEGT LNGKRGLIPQ
   781  NYVKLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 63 nTPM
  • urinary bladder: 49 nTPM
  • colon: 44 nTPM
  • skeletal muscle: 37 nTPM
  • heart muscle: 37 nTPM
  • esophagus: 35 nTPM

Single-cell type

  • esophageal apical cells: 860 nCPM
  • leydig cells: 859 nCPM
  • pericytes: 753 nCPM
  • peritubular myoid cells: 686 nCPM
  • innate lymphoid cells: 632 nCPM
  • rod photoreceptor cells: 576 nCPM

Immune cell

  • eosinophil: 17 nTPM
  • MAIT T-cell: 11 nTPM
  • memory CD8 T-cell: 6.2 nTPM
  • naive CD8 T-cell: 6 nTPM
  • T-reg: 5.4 nTPM
  • gdT-cell: 5.3 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • cerebral cortex: 15 nTPM
  • basal ganglia: 13 nTPM
  • hippocampal formation: 13 nTPM
  • thalamus: 12 nTPM
  • midbrain: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.19
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP10 as an antibody target. Whether an autoantibody or antibody against ARHGAP10 could matter depends on whether native ARHGAP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP10 is annotated at the cell surface, where native ARHGAP10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGAP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...