Seroatlas · Human Serome Atlas

ACAP3

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

Also known as: ACAP3_HUMAN, CENTB5, KIAA1716

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P50
Gene: ACAP3
Ensembl: ENSG00000131584
Chromosome: 1
Canonical length: 834 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable GTPase activator activity and zinc ion binding activity. Predicted to act upstream of or within neuron migration and regulation of neuron projection development. Predicted to be located in endosome membrane and growth cone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

834 residues, UniProt reviewed canonical sequence.

>Q96P50|ACAP3
     1  MTVEFEECVK DSPRFRATID EVETDVVEIE AKLDKLVKLC SGMVEAGKAY VSTSRLFVSG
    61  VRDLSQQCQG DTVISECLQR FADSLQEVVN YHMILFDQAQ RSVRQQLQSF VKEDVRKFKE
   121  TKKQFDKVRE DLELSLVRNA QAPRHRPHEV EEATGALTLT RKCFRHLALD YVLQINVLQA
   181  KKKFEILDSM LSFMHAQSSF FQQGYSLLHQ LDPYMKKLAA ELDQLVIDSA VEKREMERKH
   241  AAIQQRTLLQ DFSYDESKVE FDVDAPSGVV MEGYLFKRAS NAFKTWNRRW FSIQNSQLVY
   301  QKKLKDALTV VVDDLRLCSV KPCEDIERRF CFEVLSPTKS CMLQADSEKL RQAWVQAVQA
   361  SIASAYRESP DSCYSERLDR TASPSTSSID SATDTRERGV KGESVLQRVQ SVAGNSQCGD
   421  CGQPDPRWAS INLGVLLCIE CSGIHRSLGV HCSKVRSLTL DSWEPELLKL MCELGNSAVN
   481  QIYEAQCEGA GSRKPTASSS RQDKEAWIKD KYVEKKFLRK APMAPALEAP RRWRVQKCLR
   541  PHSSPRAPTA RRKVRLEPVL PCVAALSSVG TLDRKFRRDS LFCPDELDSL FSYFDAGAAG
   601  AGPRSLSSDS GLGGSSDGSS DVLAFGSGSV VDSVTEEEGA ESEESSGEAD GDTEAEAWGL
   661  ADVRELHPGL LAHRAARARD LPALAAALAH GAEVNWADAE DEGKTPLVQA VLGGSLIVCE
   721  FLLQNGADVN QRDSRGRAPL HHATLLGRTG QVCLFLKRGA DQHALDQEQR DPLAIAVQAA
   781  NADIVTLLRL ARMAEEMREA EAAPGPPGAL AGSPTELQFR RCIQEFISLH LEES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 155 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 155 nTPM
hippocampal formation: 77 nTPM
basal ganglia: 76 nTPM
cerebral cortex: 75 nTPM
amygdala: 59 nTPM
pituitary gland: 43 nTPM

Single-cell type

oligodendrocyte progenitor cells: 144 nCPM
rod photoreceptor cells: 111 nCPM
retinal bipolar cells: 102 nCPM
brain excitatory neurons: 91 nCPM
brain inhibitory neurons: 81 nCPM
oligodendrocytes: 80 nCPM

Immune cell

intermediate monocyte: 0.4 nTPM
eosinophil: 0.3 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

cerebral cortex: 54 nTPM
basal ganglia: 51 nTPM
hippocampal formation: 51 nTPM
cerebellum: 47 nTPM
white matter: 42 nTPM
thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACAP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACAP3 as an antibody target. Whether an autoantibody or antibody against ACAP3 could matter depends on whether native ACAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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