Seroatlas · Human Serome Atlas

SNX32

Sorting nexin-32

Also known as: FLJ30934, SNX32_HUMAN, SNX6B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XE0
Gene: SNX32
Ensembl: ENSG00000172803
Chromosome: 11
Canonical length: 403 aa
Protein class: Predicted intracellular proteins
Subcellular location: Focal adhesion sites,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q86XE0|SNX32
     1  METYAEVGKE GKPSCASVDL QGDSSLQVEI SDAVSERDKV KFTVQTKSCL PHFAQTEFSV
    61  VRQHEEFIWL HDAYVENEEY AGLIIPPAPP RPDFEASREK LQKLGEGDSS VTREEFAKMK
   121  QELEAEYLAI FKKTVAMHEV FLQRLAAHPT LRRDHNFFVF LEYGQDLSVR GKNRKELLGG
   181  FLRNIVKSAD EALITGMSGL KEVDDFFEHE RTFLLEYHTR IRDACLRADR VMRAHKCLAD
   241  DYIPISAALS SLGTQEVNQL RTSFLKLAEL FERLRKLEGR VASDEDLKLS DMLRYYMRDS
   301  QAAKDLLYRR LRALADYENA NKALDKARTR NREVRPAESH QQLCCQRFER LSDSAKQELM
   361  DFKSRRVSSF RKNLIELAEL ELKHAKASTL ILRNTLVALK GEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 27 nTPM
basal ganglia: 26 nTPM
hippocampal formation: 18 nTPM
amygdala: 15 nTPM
hypothalamus: 8.1 nTPM
cerebellum: 5.3 nTPM

Single-cell type

epicardial cells: 212 nCPM
cardiomyocytes: 108 nCPM
thymocytes: 85 nCPM
brain inhibitory neurons: 82 nCPM
plasma cells: 73 nCPM
paneth cells: 70 nCPM

Immune cell

MAIT T-cell: 0.7 nTPM
gdT-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
myeloid DC: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
T-reg: 0.3 nTPM

Brain region

cerebral cortex: 24 nTPM
hippocampal formation: 19 nTPM
basal ganglia: 18 nTPM
white matter: 18 nTPM
amygdala: 16 nTPM
thalamus: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX32 as an antibody target. Whether an autoantibody or antibody against SNX32 could matter depends on whether native SNX32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX32 is annotated at the cell surface, where native SNX32 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNX32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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