Seroatlas · Human Serome Atlas

BAIAP2

BAR/IMD domain-containing adapter protein 2

Also known as: BAIP2_HUMAN, BAP2, IRSp53, WAML

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQB8
Gene
BAIAP2
Ensembl
ENSG00000175866
Chromosome
17
Canonical length
552 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>Q9UQB8|BAIAP2
     1  MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK GYFDALVKMG
    61  ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE LLTQLEQKVE LDSRYLSAAL
   121  KKYQTEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVS
   181  DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPSKIPERA
   241  VQLMQQVASN GATLPSALSA SKSNLVISDP IPGAKPLPVP PELAPFVGRM SAQESTPIMN
   301  GVTGPDGEDY SPWADRKAAQ PKSLSPPQSQ SKLSDSYSNT LPVRKSVTPK NSYATTENKT
   361  LPRSSSMAAG LERNGRMRVK AIFSHAAGDN STLLSFKEGD LITLLVPEAR DGWHYGESEK
   421  TKMRGWFPFS YTRVLDSDGS DRLHMSLQQG KSSSTGNLLD KDDLAIPPPD YGAASRAFPA
   481  QTASGFKQRP YSVAVPAFSQ GLDDYGARSM SRNPFAHVQL KPTVTNDRCD LSAQGPEGRE
   541  HGDGSARTLA GR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAIAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
132 nTPM

Expression across tissuesHPA

Tissue

  • skin: 132 nTPM
  • esophagus: 132 nTPM
  • choroid plexus: 97 nTPM
  • basal ganglia: 95 nTPM
  • cerebral cortex: 88 nTPM
  • liver: 82 nTPM

Single-cell type

  • esophageal apical cells: 654 nCPM
  • alveolar cells type 2: 274 nCPM
  • esophageal suprabasal cells: 246 nCPM
  • proximal tubule cells: 241 nCPM
  • suprabasal keratinocytes: 224 nCPM
  • ocular epithelial cells: 220 nCPM

Immune cell

  • plasmacytoid DC: 21 nTPM
  • myeloid DC: 11 nTPM
  • intermediate monocyte: 10 nTPM
  • non-classical monocyte: 9.7 nTPM
  • classical monocyte: 8.7 nTPM
  • neutrophil: 5.5 nTPM

Brain region

  • hippocampal formation: 243 nTPM
  • cerebral cortex: 203 nTPM
  • basal ganglia: 193 nTPM
  • amygdala: 170 nTPM
  • hypothalamus: 154 nTPM
  • white matter: 152 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BAIAP2.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 124 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Developmental and epileptic encephalopathy 120

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.46
gnomAD missense Z
2.06
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BAIAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAIAP2 as an antibody target. Whether an autoantibody or antibody against BAIAP2 could matter depends on whether native BAIAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAIAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BAIAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BAIAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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