Seroatlas · Human Serome Atlas

ARHGAP17

Rho GTPase-activating protein 17

Also known as: FLJ10308, FLJ13219, NADRIN, RHG17_HUMAN, RICH1, WBP15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68EM7
Gene: ARHGAP17
Ensembl: ENSG00000140750
Chromosome: 16
Canonical length: 881 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

881 residues, UniProt reviewed canonical sequence.

>Q68EM7|ARHGAP17
     1  MKKQFNRMKQ LANQTVGRAE KTEVLSEDLL QIERRLDTVR SICHHSHKRL VACFQGQHGT
    61  DAERRHKKLP LTALAQNMQE ASTQLEDSLL GKMLETCGDA ENQLALELSQ HEVFVEKEIV
   121  DPLYGIAEVE IPNIQKQRKQ LARLVLDWDS VRARWNQAHK SSGTNFQGLP SKIDTLKEEM
   181  DEAGNKVEQC KDQLAADMYN FMAKEGEYGK FFVTLLEAQA DYHRKALAVL EKTLPEMRAH
   241  QDKWAEKPAF GTPLEEHLKR SGREIALPIE ACVMLLLETG MKEEGLFRIG AGASKLKKLK
   301  AALDCSTSHL DEFYSDPHAV AGALKSYLRE LPEPLMTFNL YEEWTQVASV QDQDKKLQDL
   361  WRTCQKLPPQ NFVNFRYLIK FLAKLAQTSD VNKMTPSNIA IVLGPNLLWA RNEGTLAEMA
   421  AATSVHVVAV IEPIIQHADW FFPEEVEFNV SEAFVPLTTP SSNHSFHTGN DSDSGTLERK
   481  RPASMAVMEG DLVKKESFGV KLMDFQAHRR GGTLNRKHIS PAFQPPLPPT DGSTVVPAGP
   541  EPPPQSSRAE SSSGGGTVPS SAGILEQGPS PGDGSPPKPK DPVSAAVPAP GRNNSQIASG
   601  QNQPQAAAGS HQLSMGQPHN AAGPSPHTLR RAVKKPAPAP PKPGNPPPGH PGGQSSSGTS
   661  QHPPSLSPKP PTRSPSPPTQ HTGQPPGQPS APSQLSAPRR YSSSLSPIQA PNHPPPQPPT
   721  QATPLMHTKP NSQGPPNPMA LPSEHGLEQP SHTPPQTPTP PSTPPLGKQN PSLPAPQTLA
   781  GGNPETAQPH AGTLPRPRPV PKPRNRPSVP PPPQPPGVHS AGDSSLTNTA PTASKIVTDS
   841  NSRVSEPHRS IFPEMHSDSA SKDVPGRILL DIDNDTESTA L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

spleen: 65 nTPM
blood vessel: 49 nTPM
heart muscle: 47 nTPM
adipose tissue: 45 nTPM
adrenal gland: 40 nTPM
skeletal muscle: 40 nTPM

Single-cell type

microglia: 214 nCPM
oligodendrocytes: 97 nCPM
renal connecting tubule cells: 95 nCPM
choroid plexus epithelial cells: 82 nCPM
podocytes: 74 nCPM
proximal tubule cells: 74 nCPM

Immune cell

plasmacytoid DC: 26 nTPM
memory B-cell: 25 nTPM
naive B-cell: 23 nTPM
intermediate monocyte: 18 nTPM
non-classical monocyte: 16 nTPM
myeloid DC: 15 nTPM

Brain region

white matter: 14 nTPM
medulla oblongata: 13 nTPM
pons: 12 nTPM
basal ganglia: 11 nTPM
choroid plexus: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.02
gnomAD missense Z: 1.57
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP17 as an antibody target. Whether an autoantibody or antibody against ARHGAP17 could matter depends on whether native ARHGAP17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP17 is annotated at the cell surface, where native ARHGAP17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGAP17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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