Seroatlas · Human Serome Atlas

FNBP1

Formin-binding protein 1

Also known as: FBP17, FNBP1_HUMAN, KIAA0554

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RU3
Gene
FNBP1
Ensembl
ENSG00000187239
Chromosome
9
Canonical length
617 aa
Protein class
Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q96RU3|FNBP1
     1  MSWGTELWDQ FDNLEKHTQW GIDILEKYIK FVKERTEIEL SYAKQLRNLS KKYQPKKNSK
    61  EEEEYKYTSC KAFISNLNEM NDYAGQHEVI SENMASQIIV DLARYVQELK QERKSNFHDG
   121  RKAQQHIETC WKQLESSKRR FERDCKEADR AQQYFEKMDA DINVTKADVE KARQQAQIRH
   181  QMAEDSKADY SSILQKFNHE QHEYYHTHIP NIFQKIQEME ERRIVRMGES MKTYAEVDRQ
   241  VIPIIGKCLD GIVKAAESID QKNDSQLVIE AYKSGFEPPG DIEFEDYTQP MKRTVSDNSL
   301  SNSRGEGKPD LKFGGKSKGK LWPFIKKNKL MSLLTSPHQP PPPPPASASP SAVPNGPQSP
   361  KQQKEPLSHR FNEFMTSKPK IHCFRSLKRG LSLKLGATPE DFSNLPPEQR RKKLQQKVDE
   421  LNKEIQKEMD QRDAITKMKD VYLKNPQMGD PASLDHKLAE VSQNIEKLRV ETQKFEAWLA
   481  EVEGRLPARS EQARRQSGLY DSQNPPTVNN CAQDRESPDG SYTEEQSQES EMKVLATDFD
   541  DEFDDEEPLP AIGTCKALYT FEGQNEGTIS VVEGETLYVI EEDKGDGWTR IRRNEDEEGY
   601  VPTSYVEVCL DKNAKDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
102 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 102 nTPM
  • lymph node: 73 nTPM
  • tonsil: 71 nTPM
  • spleen: 57 nTPM
  • appendix: 53 nTPM
  • smooth muscle: 44 nTPM

Single-cell type

  • cdc: 935 nCPM
  • neutrophils: 910 nCPM
  • t-cells: 884 nCPM
  • innate lymphoid cells: 812 nCPM
  • kupffer cells: 805 nCPM
  • b-cells: 794 nCPM

Immune cell

  • basophil: 13 nTPM
  • memory B-cell: 12 nTPM
  • T-reg: 11 nTPM
  • gdT-cell: 10 nTPM
  • memory CD8 T-cell: 9.7 nTPM
  • eosinophil: 9.3 nTPM

Brain region

  • white matter: 170 nTPM
  • cerebellum: 149 nTPM
  • basal ganglia: 144 nTPM
  • thalamus: 139 nTPM
  • medulla oblongata: 137 nTPM
  • midbrain: 137 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.83
gnomAD missense Z
2.02
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FNBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNBP1 as an antibody target. Whether an autoantibody or antibody against FNBP1 could matter depends on whether native FNBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNBP1 is annotated at the cell surface, where native FNBP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FNBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FNBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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