Seroatlas · Human Serome Atlas

FCHO2

F-BAR domain only protein 2

Also known as: FCHO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0JRZ9
Gene: FCHO2
Ensembl: ENSG00000157107
Chromosome: 5
Canonical length: 810 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Centrosome,Cytosol
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

810 residues, UniProt reviewed canonical sequence.

>Q0JRZ9|FCHO2
     1  MVMAYFVENF WGEKNSGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA
    61  SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA
   121  GTLEAVQTIQ SITQALQKSK ENYNAKCVEQ ERLKKEGATQ REIEKAAVKS KKATDTYKLY
   181  VEKYALAKAD FEQKMTETAQ KFQDIEETHL IHIKEIIGSL SNAIKEIHLQ IGQVHEEFIN
   241  NMANTTVESL IQKFAESKGT GKERPGLIEF EECDTASAVE GIKPRKRKTF ALPGIIKKEK
   301  DAESVECPDA DSLNIPDVDE EGYSIKPETN QNDTKENHFY SSSDSDSEDE EPKKYRIEIK
   361  PMHPNNSHHT MASLDELKVS IGNITLSPAI SRHSPVQMNR NLSNEELTKS KPSAPPNEKG
   421  TSDLLAWDPL FGPSLDSSSS SSLTSSSSAR PTTPLSVGTI VPPPRPASRP KLTSGKLSGI
   481  NEIPRPFSPP VTSNTSPPPA APLARAESSS SISSSASLSA ANTPTVGVSR GPSPVSLGNQ
   541  DTLPVAVALT ESVNAYFKGA DPTKCIVKIT GDMTMSFPSG IIKVFTSNPT PAVLCFRVKN
   601  ISRLEQILPN AQLVFSDPSQ CDSNTKDFWM NMQAVTVYLK KLSEQNPAAS YYNVDVLKYQ
   661  VSSNGIQSTP LNLATYWKCS ASTTDLRVDY KYNPEAMVAP SVLSNIQVVV PVDGGVTNMQ
   721  SLPPAIWNAE QMKAFWKLSS ISEKSENGGS GSLRAKFDLS EGPSKPTTLA VQFLSEGSTL
   781  SGVDFELVGT GYRLSLIKKR FATGRYLADC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCHO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

esophagus: 28 nTPM
thyroid gland: 23 nTPM
lung: 21 nTPM
placenta: 20 nTPM
kidney: 18 nTPM
small intestine: 18 nTPM

Single-cell type

esophageal apical cells: 767 nCPM
kupffer cells: 391 nCPM
alveolar cells type 2: 346 nCPM
macrophages: 317 nCPM
transitional alveolar cells: 285 nCPM
neutrophils: 273 nCPM

Immune cell

neutrophil: 21 nTPM
basophil: 19 nTPM
eosinophil: 8.8 nTPM
non-classical monocyte: 6.6 nTPM
intermediate monocyte: 4.6 nTPM
classical monocyte: 3.2 nTPM

Brain region

choroid plexus: 30 nTPM
cerebellum: 27 nTPM
thalamus: 26 nTPM
white matter: 25 nTPM
medulla oblongata: 20 nTPM
basal ganglia: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 2.02
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

FCH domain
Muniscin, C-terminal
AH/BAR domain superfamily
Mu homology domain
F-BAR domain
GMIP/FCHO2-like, FCH domain
Muniscin C-terminal mu homology domain
GEM-interacting protein-like, FCH domain
F-BAR domain only protein 2, F-BAR domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FCHO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCHO2 as an antibody target. Whether an autoantibody or antibody against FCHO2 could matter depends on whether native FCHO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCHO2 is annotated at the cell surface, where native FCHO2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FCHO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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