Seroatlas · Human Serome Atlas

ACAP2

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Also known as: ACAP2_HUMAN, CENTB2, CNT-B2, KIAA0041

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15057
Gene
ACAP2
Ensembl
ENSG00000114331
Chromosome
3
Canonical length
778 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Endosomes

OverviewNCBI Gene

Enables GTPase activator activity. Acts upstream of or within actin filament-based process. Located in ruffle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

778 residues, UniProt reviewed canonical sequence.

>Q15057|ACAP2
     1  MKMTVDFEEC LKDSPRFRAA LEEVEGDVAE LELKLDKLVK LCIAMIDTGK AFCVANKQFM
    61  NGIRDLAQYS SNDAVVETSL TKFSDSLQEM INFHTILFDQ TQRSIKAQLQ NFVKEDLRKF
   121  KDAKKQFEKV SEEKENALVK NAQVQRNKQH EVEEATNILT ATRKCFRHIA LDYVLQINVL
   181  QSKRRSEILK SMLSFMYAHL AFFHQGYDLF SELGPYMKDL GAQLDRLVVD AAKEKREMEQ
   241  KHSTIQQKDF SSDDSKLEYN VDAANGIVME GYLFKRASNA FKTWNRRWFS IQNNQLVYQK
   301  KFKDNPTVVV EDLRLCTVKH CEDIERRFCF EVVSPTKSCM LQADSEKLRQ AWIKAVQTSI
   361  ATAYREKGDE SEKLDKKSSP STGSLDSGNE SKEKLLKGES ALQRVQCIPG NASCCDCGLA
   421  DPRWASINLG ITLCIECSGI HRSLGVHFSK VRSLTLDTWE PELLKLMCEL GNDVINRVYE
   481  ANVEKMGIKK PQPGQRQEKE AYIRAKYVER KFVDKYSISL SPPEQQKKFV SKSSEEKRLS
   541  ISKFGPGDQV RASAQSSVRS NDSGIQQSSD DGRESLPSTV SANSLYEPEG ERQDSSMFLD
   601  SKHLNPGLQL YRASYEKNLP KMAEALAHGA DVNWANSEEN KATPLIQAVL GGSLVTCEFL
   661  LQNGANVNQR DVQGRGPLHH ATVLGHTGQV CLFLKRGANQ HATDEEGKDP LSIAVEAANA
   721  DIVTLLRLAR MNEEMRESEG LYGQPGDETY QDIFRDFSQM ASNNPEKLNR FQQDSQKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 33 nTPM
  • tonsil: 25 nTPM
  • lymph node: 23 nTPM
  • spleen: 22 nTPM
  • retina: 22 nTPM
  • appendix: 20 nTPM

Single-cell type

  • neutrophils: 2,226 nCPM
  • neutrophil progenitors: 1,126 nCPM
  • esophageal apical cells: 609 nCPM
  • pituicytes/fscs: 548 nCPM
  • retinal horizontal cells: 543 nCPM
  • monocytes: 467 nCPM

Immune cell

  • neutrophil: 227 nTPM
  • basophil: 66 nTPM
  • non-classical monocyte: 63 nTPM
  • eosinophil: 59 nTPM
  • classical monocyte: 58 nTPM
  • intermediate monocyte: 51 nTPM

Brain region

  • cerebellum: 55 nTPM
  • hippocampal formation: 46 nTPM
  • cerebral cortex: 45 nTPM
  • basal ganglia: 43 nTPM
  • amygdala: 43 nTPM
  • hypothalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.92
gnomAD missense Z
3.22
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACAP2 as an antibody target. Whether an autoantibody or antibody against ACAP2 could matter depends on whether native ACAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACAP2 is annotated at the cell surface, where native ACAP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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