Seroatlas · Human Serome Atlas

SNX9

Sorting nexin-9

Also known as: SDP1, SH3PX1, SH3PXD3A, SNX9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5X1
Gene
SNX9
Ensembl
ENSG00000130340
Chromosome
6
Canonical length
595 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q9Y5X1|SNX9
     1  MATKARVMYD FAAEPGNNEL TVNEGEIITI TNPDVGGGWL EGRNIKGERG LVPTDYVEIL
    61  PSDGKDQFSC GNSVADQAFL DSLSASTAQA SSSAASNNHQ VGSGNDPWSA WSASKSGNWE
   121  SSEGWGAQPE GAGAQRNTNT PNNWDTAFGH PQAYQGPATG DDDDWDEDWD GPKSSSYFKD
   181  SESADAGGAQ RGNSRASSSS MKIPLNKFPG FAKPGTEQYL LAKQLAKPKE KIPIIVGDYG
   241  PMWVYPTSTF DCVVADPRKG SKMYGLKSYI EYQLTPTNTN RSVNHRYKHF DWLYERLLVK
   301  FGSAIPIPSL PDKQVTGRFE EEFIKMRMER LQAWMTRMCR HPVISESEVF QQFLNFRDEK
   361  EWKTGKRKAE RDELAGVMIF STMEPEAPDL DLVEIEQKCE AVGKFTKAMD DGVKELLTVG
   421  QEHWKRCTGP LPKEYQKIGK ALQSLATVFS SSGYQGETDL NDAITEAGKT YEEIASLVAE
   481  QPKKDLHFLM ECNHEYKGFL GCFPDIIGTH KGAIEKVKES DKLVATSKIT LQDKQNMVKR
   541  VSIMSYALQA EMNHFHSNRI YDYNSVIRLY LEQQVQFYET IAEKLRQALS RFPVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 68 nTPM
  • adipose tissue: 64 nTPM
  • esophagus: 54 nTPM
  • urinary bladder: 47 nTPM
  • breast: 46 nTPM
  • placenta: 46 nTPM

Single-cell type

  • endometrial glandular cells: 2,922 nCPM
  • endometrial luminal cells: 2,424 nCPM
  • esophageal apical cells: 1,152 nCPM
  • monocytes: 834 nCPM
  • b-cells: 649 nCPM
  • macrophages: 621 nCPM

Immune cell

  • plasmacytoid DC: 10 nTPM
  • non-classical monocyte: 6.9 nTPM
  • naive CD4 T-cell: 5.4 nTPM
  • memory B-cell: 3.3 nTPM
  • naive B-cell: 2.6 nTPM
  • intermediate monocyte: 2.2 nTPM

Brain region

  • white matter: 18 nTPM
  • medulla oblongata: 17 nTPM
  • cerebellum: 15 nTPM
  • midbrain: 15 nTPM
  • spinal cord: 14 nTPM
  • thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.71
gnomAD missense Z
1.82
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX9 as an antibody target. Whether an autoantibody or antibody against SNX9 could matter depends on whether native SNX9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX9 is annotated at the cell surface, where native SNX9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNX9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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