Seroatlas · Human Serome Atlas

SNX5

Sorting nexin-5

Also known as: SNX5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5X3
Gene
SNX5
Ensembl
ENSG00000089006
Chromosome
20
Canonical length
404 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>Q9Y5X3|SNX5
     1  MAAVPELLQQ QEEDRSKLRS VSVDLNVDPS LQIDIPDALS ERDKVKFTVH TKTTLPTFQS
    61  PEFSVTRQHE DFVWLHDTLI ETTDYAGLII PPAPTKPDFD GPREKMQKLG EGEGSMTKEE
   121  FAKMKQELEA EYLAVFKKTV SSHEVFLQRL SSHPVLSKDR NFHVFLEYDQ DLSVRRKNTK
   181  EMFGGFFKSV VKSADEVLFT GVKEVDDFFE QEKNFLINYY NRIKDSCVKA DKMTRSHKNV
   241  ADDYIHTAAC LHSLALEEPT VIKKYLLKVA ELFEKLRKVE GRVSSDEDLK LTELLRYYML
   301  NIEAAKDLLY RRTKALIDYE NSNKALDKAR LKSKDVKLAE AHQQECCQKF EQLSESAKEE
   361  LINFKRKRVA AFRKNLIEMS ELEIKHARNN VSLLQSCIDL FKNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 66 nTPM
  • thyroid gland: 66 nTPM
  • kidney: 55 nTPM
  • lymph node: 55 nTPM
  • bone marrow: 54 nTPM
  • spleen: 52 nTPM

Single-cell type

  • kupffer cells: 301 nCPM
  • hofbauer cells: 216 nCPM
  • extravillous trophoblasts: 157 nCPM
  • epididymal principal cells: 130 nCPM
  • megakaryocyte-erythroid progenitors: 123 nCPM
  • migrating cytotrophoblasts: 123 nCPM

Immune cell

  • non-classical monocyte: 93 nTPM
  • eosinophil: 84 nTPM
  • intermediate monocyte: 82 nTPM
  • memory B-cell: 81 nTPM
  • naive B-cell: 76 nTPM
  • myeloid DC: 72 nTPM

Brain region

  • white matter: 57 nTPM
  • spinal cord: 49 nTPM
  • medulla oblongata: 47 nTPM
  • cerebellum: 43 nTPM
  • basal ganglia: 43 nTPM
  • choroid plexus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
0.14
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX5 as an antibody target. Whether an autoantibody or antibody against SNX5 could matter depends on whether native SNX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX5 is annotated at the cell surface, where native SNX5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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