Seroatlas · Human Serome Atlas

SRGAP2

SLIT-ROBO Rho GTPase-activating protein 2

Also known as: ARHGAP34, FNBP2, KIAA0456, SRGAP2A, SRGP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75044
Gene: SRGAP2
Ensembl: ENSG00000266028
Chromosome: 1
Canonical length: 1071 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Centrosome,Basal body,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

1071 residues, UniProt reviewed canonical sequence.

>O75044|SRGAP2
     1  MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE
    61  MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY
   121  LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK
   181  LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT
   241  ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDQCC DLGYHASLNR ALRTFLSAEL
   301  NLEQSKHEGL DAIENAVENL DATSDKQRLM EMYNNVFCPP MKFEFQPHMG DMASQLCAQQ
   361  PVQSELVQRC QQLQSRLSTL KIENEEVKKT MEATLQTIQD IVTVEDFDVS DCFQYSNSME
   421  SVKSTVSETF MSKPSIAKRR ANQQETEQFY FTKMKEYLEG RNLITKLQAK HDLLQKTLGE
   481  SQRTDCSLAR RSSTVRKQDS SQAIPLVVES CIRFISRHGL QHEGIFRVSG SQVEVNDIKN
   541  AFERGEDPLA GDQNDHDMDS IAGVLKLYFR GLEHPLFPKD IFHDLMACVT MDNLQERALH
   601  IRKVLLVLPK TTLIIMRYLF AFLNHLSQFS EENMMDPYNL AICFGPSLMS VPEGHDQVSC
   661  QAHVNELIKT IIIQHENIFP SPRELEGPVY SRGGSMEDYC DSPHGETTSV EDSTQDVTAE
   721  HHTSDDECEP IEAIAKFDYV GRTARELSFK KGASLLLYQR ASDDWWEGRH NGIDGLIPHQ
   781  YIVVQDTEDG VVERSSPKSE IEVISEPPEE KVTARAGASC PSGGHVADIY LANINKQRKR
   841  PESGSIRKTF RSDSHGLSSS LTDSSSPGVG ASCRPSSQPI MSQSLPKEGP DKCSISGHGS
   901  LNSISRHSSL KNRLDSPQIR KTATAGRSKS FNNHRPMDPE VIAQDIEATM NSALNELREL
   961  ERQSSVKHTP DVVLDTLEPL KTSPVVAPTS EPSSPLHTQL LKDPEPAFQR SASTAGDIAC
  1021  AFRPVKSVKM AAPVKPPATR PKPTVFPKTN ATSPGVNSST SPQSTDKSCT V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRGAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 123 nTPM
skin: 40 nTPM
spinal cord: 27 nTPM
parathyroid gland: 23 nTPM
spleen: 22 nTPM
cerebral cortex: 21 nTPM

Single-cell type

microglia: 2,480 nCPM
podocytes: 1,255 nCPM
macrophages: 323 nCPM
brain excitatory neurons: 273 nCPM
cdc: 211 nCPM
monocytes: 208 nCPM

Immune cell

non-classical monocyte: 10 nTPM
intermediate monocyte: 8.6 nTPM
plasmacytoid DC: 8.4 nTPM
classical monocyte: 6.7 nTPM
myeloid DC: 6.1 nTPM
neutrophil: 5.9 nTPM

Brain region

cerebellum: 196 nTPM
pons: 113 nTPM
white matter: 108 nTPM
medulla oblongata: 96 nTPM
cerebral cortex: 94 nTPM
spinal cord: 91 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
gnomAD missense Z: 3.19

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRGAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRGAP2 as an antibody target. Whether an autoantibody or antibody against SRGAP2 could matter depends on whether native SRGAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRGAP2 is annotated at the cell surface, where native SRGAP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SRGAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...