Seroatlas · Human Serome Atlas

MTSS2

Protein MTSS 2

Also known as: ABBA, ABBA-1, LOC92154, MTSS1L, MTSS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q765P7
Gene
MTSS2
Ensembl
ENSG00000132613
Chromosome
16
Canonical length
747 aa
Protein class
Predicted intracellular proteins
Subcellular location
Focal adhesion sites

OverviewNCBI Gene

Enables GTPase activator activity and small GTPase binding activity. Involved in activation of GTPase activity and cellular response to platelet-derived growth factor stimulus. Located in ruffle membrane. Implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>Q765P7|MTSS2
     1  METAEKECGA LGGLFQAIVN DMKSSYPIWE DFNSKATKLH SQLRTTVLAA VAFLDAFQKV
    61  ADMATNTRGA TRDIGSALTR MCMRHRSIET KLRQFTNALL ESLINPLQER IEDWKKAANQ
   121  LDKDHAKEYK RARHEIKKKS SDTLKLQKKA RKELLGKGDL QPQLDSALQD VNDMYLLLEE
   181  TEKQAVRRAL IEERGRFCTF ITFLQPVVNG ELTMLGEITH LQGIIDDLVV LTAEPHKLPP
   241  ASEQVIKDLK GSDYSWSYQT PPSSPSSSSS RKSSMCSAPS SSSSAKGGGA PWPGGAQTYS
   301  PSSTCRYRSL AQPATTTARL SSVSSHDSGF VSQDATYSKP PSPMPSDITS QKSSSSASSE
   361  ASETCQSVSE CSSPTSDWSK VGSHEQPSGA TLQRRKDRVE LLRDTEPGPA SGGTLGPSGE
   421  EAPRPRMSPA TIAAKHGEEV SPAASDLAMV LTRGLSLEHQ KSSRDSLQYS SGYSTQTTTP
   481  SCSEDTIPSQ GSDYDCYSVN GDADSEGPPE FDKSSTIPRN SNIAQNYRRL IQTKRPASTA
   541  GLPTAGLPTA TGLPSGAPPG VATIRRTPST KPTVRRALSS AGPIPIRPPI VPVKTPTVPD
   601  SPGYMGPTRA GSEECVFYTD ETASPLAPDL AKASPKRLSL PNTAWGSPSP EAAGYPGAGA
   661  EDEQQQLAAN RHSLVEKLGE LVAGAHALGE GQFPFPTALS ATPTEETPTP PPAATSDPPA
   721  EDMLVAIRRG VRLRRTVTND RSAPRIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTSS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
289 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 289 nTPM
  • spinal cord: 268 nTPM
  • midbrain: 258 nTPM
  • hippocampal formation: 255 nTPM
  • cerebral cortex: 254 nTPM
  • basal ganglia: 228 nTPM

Single-cell type

  • bergmann glia: 469 nCPM
  • oligodendrocyte progenitor cells: 291 nCPM
  • astrocytes: 276 nCPM
  • extravillous trophoblasts: 146 nCPM
  • ependymal cells: 140 nCPM
  • retinal pigment epithelial cells: 94 nCPM

Immune cell

  • MAIT T-cell: 0.5 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • medulla oblongata: 787 nTPM
  • hypothalamus: 698 nTPM
  • thalamus: 681 nTPM
  • midbrain: 666 nTPM
  • amygdala: 626 nTPM
  • basal ganglia: 623 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MTSS2.

Disease | AllUniProt

Conditions MTSS2 is implicated in, by any mechanism.

  • Intellectual developmental disorder with ocular anomalies and distinctive facial features (IDDOF) MIM:620086

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 248 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTSS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTSS2 as an antibody target. Whether an autoantibody or antibody against MTSS2 could matter depends on whether native MTSS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTSS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTSS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MTSS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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