Seroatlas · Human Serome Atlas

FES

Tyrosine-protein kinase Fes/Fps

Also known as: FES_HUMAN, FPS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07332
Gene
FES
Ensembl
ENSG00000182511
Chromosome
15
Canonical length
822 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

822 residues, UniProt reviewed canonical sequence.

>P07332|FES
     1  MGFSSELCSP QGHGVLQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH MSLQDSGGQS
    61  RAISPDSPIS QSWAEITSQT EGLSRLLRQH AEDLNSGPLS KLSLLIRERQ QLRKTYSEQW
   121  QQLQQELTKT HSQDIEKLKS QYRALARDSA QAKRKYQEAS KDKDRDKAKD KYVRSLWKLF
   181  AHHNRYVLGV RAAQLHHQHH HQLLLPGLLR SLQDLHEEMA CILKEILQEY LEISSLVQDE
   241  VVAIHREMAA AAARIQPEAE YQGFLRQYGS APDVPPCVTF DESLLEEGEP LEPGELQLNE
   301  LTVESVQHTL TSVTDELAVA TEMVFRRQEM VTQLQQELRN EEENTHPRER VQLLGKRQVL
   361  QEALQGLQVA LCSQAKLQAQ QELLQTKLEH LGPGEPPPVL LLQDDRHSTS SSEQEREGGR
   421  TPTLEILKSH ISGIFRPKFS LPPPLQLIPE VQKPLHEQLW YHGAIPRAEV AELLVHSGDF
   481  LVRESQGKQE YVLSVLWDGL PRHFIIQSLD NLYRLEGEGF PSIPLLIDHL LSTQQPLTKK
   541  SGVVLHRAVP KDKWVLNHED LVLGEQIGRG NFGEVFSGRL RADNTLVAVK SCRETLPPDL
   601  KAKFLQEARI LKQYSHPNIV RLIGVCTQKQ PIYIVMELVQ GGDFLTFLRT EGARLRVKTL
   661  LQMVGDAAAG MEYLESKCCI HRDLAARNCL VTEKNVLKIS DFGMSREEAD GVYAASGGLR
   721  QVPVKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGASP YPNLSNQQTR EFVEKGGRLP
   781  CPELCPDAVF RLMEQCWAYE PGQRPSFSTI YQELQSIRKR HR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FES can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 110 nTPM
  • bone marrow: 79 nTPM
  • salivary gland: 55 nTPM
  • lung: 30 nTPM
  • adipose tissue: 30 nTPM
  • liver: 25 nTPM

Single-cell type

  • neutrophils: 128 nCPM
  • neutrophil progenitors: 120 nCPM
  • tuft cells: 104 nCPM
  • kupffer cells: 103 nCPM
  • monocytes: 97 nCPM
  • hofbauer cells: 84 nCPM

Immune cell

  • eosinophil: 317 nTPM
  • myeloid DC: 163 nTPM
  • classical monocyte: 152 nTPM
  • neutrophil: 101 nTPM
  • intermediate monocyte: 89 nTPM
  • total PBMC: 81 nTPM

Brain region

  • medulla oblongata: 12 nTPM
  • thalamus: 12 nTPM
  • spinal cord: 11 nTPM
  • pons: 10 nTPM
  • cerebral cortex: 10 nTPM
  • white matter: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
1.76
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FES in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FES as an antibody target. Whether an autoantibody or antibody against FES could matter depends on whether native FES is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FES is annotated at the cell surface, where native FES is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FES as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FES. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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