Seroatlas · Human Serome Atlas

FCHSD1

F-BAR and double SH3 domains protein 1

Also known as: FCSD1_HUMAN, FLJ00007

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WN1
Gene: FCHSD1
Ensembl: ENSG00000197948
Chromosome: 5
Canonical length: 690 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable lipid binding activity. Predicted to be involved in neuromuscular synaptic transmission and positive regulation of actin filament polymerization. Predicted to act upstream of or within several processes, including import into nucleus; inflammatory response; and response to hydrogen peroxide. Predicted to be located in cuticular plate. Predicted to be part of protein-containing complex. Predicted to be active in cytosol; neuromuscular junction; and recycling endosome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

690 residues, UniProt reviewed canonical sequence.

>Q86WN1|FCHSD1
     1  MQPPPRKVKP AQEVKLRFLE QLSILQTWQQ READLLEDIR SYSKQRAAIE REYGQALQKL
    61  AGPFLKREGH RSGEMDSRGR TVFGAWRCLL DATVAGGQTR LQASDRYRDL AGGTGRSAKE
   121  QVLRKGTENL QRAQAEVLQS VRELSRSRKL YGQRERVWAL AQEKAADVQA RLNRSDHGIF
   181  HSRTSLQKLS TKLSAQSAQY SQQLQAARNE YLLNLVATNA HLDHYYQEEL PALLKALVSE
   241  LSEHLRDPLT SLSHTELEAA EVILEHAHRG EQTTSQVSWE QDLKLFLQEP GVFSPTPPQQ
   301  FQPAGTDQVC VLEWGAEGVA GKSGLEKEVQ RLTSRAARDY KIQNHGHRVL QRLEQRRQQA
   361  SEREAPSIEQ RLQEVRESIR RAQVSQVKGA ARLALLQGAG LDVERWLKPA MTQAQDEVEQ
   421  ERRLSEARLS QRDLSPTAED AELSDFEECE ETGELFEEPA PQALATRALP CPAHVVFRYQ
   481  AGREDELTIT EGEWLEVIEE GDADEWVKAR NQHGEVGFVP ERYLNFPDLS LPESSQDSDN
   541  PCGAEPTAFL AQALYSYTGQ SAEELSFPEG ALIRLLPRAQ DGVDDGFWRG EFGGRVGVFP
   601  SLLVEELLGP PGPPELSDPE QMLPSPSPPS FSPPAPTSVL DGPPAPVLPG DKALDFPGFL
   661  DMMAPRLRPM RPPPPPPAKA PDPGHPDPLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCHSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 48 nTPM
lymph node: 22 nTPM
spleen: 21 nTPM
skin: 20 nTPM
bone marrow: 19 nTPM
appendix: 18 nTPM

Single-cell type

retinal horizontal cells: 54 nCPM
neutrophils: 14 nCPM
epicardial cells: 14 nCPM
microglia: 13 nCPM
t-cells: 12 nCPM
tuft cells: 12 nCPM

Immune cell

neutrophil: 6.5 nTPM
basophil: 5.8 nTPM
memory CD8 T-cell: 4.6 nTPM
gdT-cell: 4.3 nTPM
eosinophil: 4 nTPM
T-reg: 3.5 nTPM

Brain region

pons: 21 nTPM
hypothalamus: 21 nTPM
medulla oblongata: 21 nTPM
thalamus: 20 nTPM
white matter: 20 nTPM
cerebellum: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FCHSD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCHSD1 as an antibody target. Whether an autoantibody or antibody against FCHSD1 could matter depends on whether native FCHSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCHSD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FCHSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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