Seroatlas · Protein domains

PAC1/LIS1-like, WD-40 repeat

IPR020472

Definition

This entry represents the WD-40 repeats in PAC1/LIS1 receptors, a class B G-protein-coupled receptor (GPCR) and similar GPCR related proteins. This entry also includes small ribosomal subunit proteins RACK1 and other scaffolding proteins such as CIAO1 and MDV1. WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed β-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised β-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein or protein-DNA interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins PMID:30069656. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a β-propeller), TAFII transcription factor, and E3 ubiquitin ligase [[cite:PMID:11814058], [cite:PMID:10322433]]. In Arabidopsis spp., several WD40-containing proteins act as key regulators of plant-specific developmental events.

84 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

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