Seroatlas · Human Serome Atlas

FBXW10

F-box/WD repeat-containing protein 10

Also known as: C17orf1, C17orf1A, Fbw10, FBW10_HUMAN, HREP, SM2SH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5XX13
Gene: FBXW10
Ensembl: ENSG00000171931
Chromosome: 17
Canonical length: 1052 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1052 residues, UniProt reviewed canonical sequence.

>Q5XX13|FBXW10
     1  MENLESRLKN APYFRCEKGT DSIPLCRKCE TCVLAWKIFS TKEWFCRIND ISQRRFLVGI
    61  LKQLNSLYLL HYFQNILQTT QGKDFIYNRS RINLSKKEGK VVKSSLNQML DKTVEQKMKE
   121  ILYWFANSTQ WTKANYTLLL LQMCNPKLLL TAANVIRVLF LREENNISGL NQDITDVCFS
   181  PEKDHSSKSA TSQVYWTAKT QHTSLPLSKA PENEHLLGAA SNPEEPWRNS LRCISEMNRL
   241  FSGKGDITKP GYDPCNLLVD LDDIRDLSSG FSKYRDFIRY LPIHLSKYIL RMLDRHTLNK
   301  CASVSQHWAA MAQQVKMDLS AHGFIQNQIT FLQGSYTRGI DPNYANKVSI PVPKMVDDGK
   361  SMRVKHPKWK LRTKNEYNLW TAYQNEETQQ VLIEERNVFC GTYNVRILSD TWDQNRVIHY
   421  SGGDLIAVSS NRKIHLLDII QVKAIPVEFR GHAGSVRALF LCEEENFLLS GSYDLSIRYW
   481  DLKSGVCTRI FGGHQGTITC MDLCKNRLVS GGRDCQVKVW DVDTGKCLKT FRHKDPILAT
   541  RINDTYIVSS CERGLVKVWH IAMAQLVKTL SGHEGAVKCL FFDQWHLLSG STDGLVMAWS
   601  MVGKYERCLM AFKHPKEVLD VSLLFLRVIS ACADGKIRIY NFLNGNCMKV LKANGRGDPV
   661  LSFFIQGNRM VVNTESNVLM FQFEHIKWQY AVEKTKQKKN KEKEEEKEEN SLMEILSKCN
   721  IQVHSPRESV SSKQTVIQEL LPGKPPKSRV LLKPAKFSSA VLIEELQSQG KSKSPRRDAD
   781  DVEKAQKQGQ LETPGKLPSH PKKKSWKIPM SPDQFLLTVS ALQHAHNSGE FAYPCRPQTE
   841  ITDVWGPSIS YPRKVLNFKG KSIQRAVDRL RLSNPPIDVK RTSIPLEIQK LQPNLKISLH
   901  SPRVQSTIPQ PMIIRSRFSG SLKGGDQVTS SIERAVCSTG PLTSMQVIKP NRMLAPQVGT
   961  ATLSLKKERP RIYTALDPFR VNTEFVLLTV KEEKEHQEAK MKEYQAREST GVVDPGKVSK
  1021  AAWIRKIKGL PIDNFTKQGK TAAPELGQNV FI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXW10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

testis: 9.1 nTPM
cerebellum: 1.3 nTPM
liver: 0.8 nTPM
thyroid gland: 0.8 nTPM
choroid plexus: 0.7 nTPM
epididymis: 0.6 nTPM

Single-cell type

early spermatids: 63 nCPM
late primary spermatocytes: 31 nCPM
late spermatids: 20 nCPM
tuft cells: 12 nCPM
respiratory ciliated cells: 9.1 nCPM
retinal ganglion cells: 7.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 1.1 nTPM
cerebellum: 1 nTPM
medulla oblongata: 0.8 nTPM
cerebral cortex: 0.7 nTPM
basal ganglia: 0.6 nTPM
choroid plexus: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 1
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXW10 as an antibody target. Whether an autoantibody or antibody against FBXW10 could matter depends on whether native FBXW10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXW10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXW10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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