Seroatlas · Human Serome Atlas

WDR37

WD repeat-containing protein 37

Also known as: KIAA0982, WDR37_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2I8
Gene
WDR37
Ensembl
ENSG00000047056
Chromosome
10
Canonical length
494 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Intermediate filaments
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>Q9Y2I8|WDR37
     1  MPTESASCST ARQTKQKRKS HSLSIRRTNS SEQERTGLPR DMLEGQDSKL PSSVRSTLLE
    61  LFGQIEREFE NLYIENLELR REIDTLNERL AAEGQAIDGA ELSKGQLKTK ASHSTSQLSQ
   121  KLKTTYKAST SKIVSSFKTT TSRAACQLVK EYIGHRDGIW DVSVAKTQPV VLGTASADHT
   181  ALLWSIETGK CLVKYAGHVG SVNSIKFHPS EQLALTASGD QTAHIWRYAV QLPTPQPVAD
   241  TSISGEDEVE CSDKDEPDLD GDVSSDCPTI RVPLTSLKSH QGVVIASDWL VGGKQAVTAS
   301  WDRTANLYDV ETSELVHSLT GHDQELTHCC THPTQRLVVT SSRDTTFRLW DFRDPSIHSV
   361  NVFQGHTDTV TSAVFTVGDN VVSGSDDRTV KVWDLKNMRS PIATIRTDSA INRINVCVGQ
   421  KIIALPHDNR QVRLFDMSGV RLARLPRSSR QGHRRMVCCS AWSEDHPVCN LFTCGFDRQA
   481  IGWNINIPAL LQEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 20 nTPM
  • testis: 20 nTPM
  • skeletal muscle: 17 nTPM
  • adrenal gland: 16 nTPM
  • heart muscle: 15 nTPM
  • bone marrow: 15 nTPM

Single-cell type

  • early spermatids: 373 nCPM
  • neutrophil progenitors: 226 nCPM
  • neutrophils: 225 nCPM
  • retinal ganglion cells: 213 nCPM
  • myonuclei: 209 nCPM
  • cardiomyocytes: 192 nCPM

Immune cell

  • NK-cell: 12 nTPM
  • gdT-cell: 9.5 nTPM
  • MAIT T-cell: 9.1 nTPM
  • non-classical monocyte: 7.4 nTPM
  • memory CD8 T-cell: 6.6 nTPM
  • naive CD8 T-cell: 6.6 nTPM

Brain region

  • cerebral cortex: 79 nTPM
  • basal ganglia: 56 nTPM
  • white matter: 56 nTPM
  • hippocampal formation: 53 nTPM
  • amygdala: 51 nTPM
  • pons: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR37.

Disease | AllUniProt

Conditions WDR37 is implicated in, by any mechanism.

  • Neurooculocardiogenitourinary syndrome (NOCGUS) MIM:618652

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.57
gnomAD missense Z
2.31
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR37 as an antibody target. Whether an autoantibody or antibody against WDR37 could matter depends on whether native WDR37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR37. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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