Seroatlas · Human Serome Atlas

TBL2

Transducin beta-like protein 2

Also known as: DKFZP43N024, TBL2_HUMAN, WBSCR13, WS-betaTRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y4P3
Gene
TBL2
Ensembl
ENSG00000106638
Chromosome
7
Canonical length
447 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q9Y4P3|TBL2
     1  MELSQMSELM GLSVLLGLLA LMATAAVARG WLRAGEERSG RPACQKANGF PPDKSSGSKK
    61  QKQYQRIRKE KPQQHNFTHR LLAAALKSHS GNISCMDFSS NGKYLATCAD DRTIRIWSTK
   121  DFLQREHRSM RANVELDHAT LVRFSPDCRA FIVWLANGDT LRVFKMTKRE DGGYTFTATP
   181  EDFPKKHKAP VIDIGIANTG KFIMTASSDT TVLIWSLKGQ VLSTINTNQM NNTHAAVSPC
   241  GRFVASCGFT PDVKVWEVCF GKKGEFQEVV RAFELKGHSA AVHSFAFSND SRRMASVSKD
   301  GTWKLWDTDV EYKKKQDPYL LKTGRFEEAA GAAPCRLALS PNAQVLALAS GSSIHLYNTR
   361  RGEKEECFER VHGECIANLS FDITGRFLAS CGDRAVRLFH NTPGHRAMVE EMQGHLKRAS
   421  NESTRQRLQQ QLTQAQETLK SLGALKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • pancreas: 5.8 nTPM
  • salivary gland: 5 nTPM
  • epididymis: 3.1 nTPM
  • adrenal gland: 3 nTPM
  • parathyroid gland: 2.2 nTPM

Single-cell type

  • late spermatids: 764 nCPM
  • late primary spermatocytes: 749 nCPM
  • early spermatids: 362 nCPM
  • early primary spermatocytes: 130 nCPM
  • extravillous trophoblasts: 74 nCPM
  • cytotrophoblasts: 56 nCPM

Immune cell

  • basophil: 11 nTPM
  • myeloid DC: 9.2 nTPM
  • classical monocyte: 7 nTPM
  • NK-cell: 5.6 nTPM
  • total PBMC: 5.4 nTPM
  • plasmacytoid DC: 5.2 nTPM

Brain region

  • cerebellum: 4.8 nTPM
  • choroid plexus: 4.5 nTPM
  • cerebral cortex: 3.2 nTPM
  • hippocampal formation: 2.9 nTPM
  • pons: 2.7 nTPM
  • basal ganglia: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBL2 as an antibody target. Whether an autoantibody or antibody against TBL2 could matter depends on whether native TBL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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