Seroatlas · Human Serome Atlas

KATNB1

Katanin p80 WD40 repeat-containing subunit B1

Also known as: KTNB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVA0
Gene
KATNB1
Ensembl
ENSG00000140854
Chromosome
16
Canonical length
655 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Microtubules,Cytosol

OverviewNCBI Gene

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

655 residues, UniProt reviewed canonical sequence.

>Q9BVA0|KATNB1
     1  MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT
    61  GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV
   121  ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV RCLRFSPDGK WLASAADDHT VKLWDLTAGK
   181  MMSEFPGHTG PVNVVEFHPN EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN
   241  PDGCCLYSGC QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV
   301  DLTRVTRTGT VARDPVQDHR PLAQPLPNPS APLRRIYERP STTCSKPQRV KQNSESERRS
   361  PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS EPFPAPPEDD AATAKEAAKP
   421  SPAMDVQFPV PNLEVLPRPP VVASTPAPKA EPAIIPATRN EPIGLKASDF LPAVKIPQQA
   481  ELVDEDAMSQ IRKGHDTMCV VLTSRHKNLD TVRAVWTMGD IKTSVDSAVA INDLSVVVDL
   541  LNIVNQKASL WKLDLCTTVL PQIEKLLQSK YESYVQTGCT SLKLILQRFL PLITDMLAAP
   601  PSVGVDISRE ERLHKCRLCY KQLKSISGLV KSKSGLSGRH GSTFRELHLL MASLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KATNB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 44 nTPM
  • testis: 36 nTPM
  • basal ganglia: 33 nTPM
  • skin: 29 nTPM
  • hippocampal formation: 26 nTPM
  • amygdala: 24 nTPM

Single-cell type

  • late primary spermatocytes: 135 nCPM
  • early spermatids: 106 nCPM
  • respiratory ciliated cells: 55 nCPM
  • fallopian tube ciliated cells: 47 nCPM
  • platelets: 44 nCPM
  • late spermatids: 36 nCPM

Immune cell

  • basophil: 51 nTPM
  • eosinophil: 46 nTPM
  • neutrophil: 28 nTPM
  • non-classical monocyte: 23 nTPM
  • total PBMC: 22 nTPM
  • gdT-cell: 21 nTPM

Brain region

  • cerebral cortex: 62 nTPM
  • hippocampal formation: 46 nTPM
  • basal ganglia: 45 nTPM
  • white matter: 44 nTPM
  • hypothalamus: 38 nTPM
  • amygdala: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KATNB1.

Disease | AllUniProt

Conditions KATNB1 is implicated in, by any mechanism.

  • Lissencephaly 6, with microcephaly (LIS6) MIM:616212

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 437 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
gnomAD missense Z
1.64
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KATNB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KATNB1 as an antibody target. Whether an autoantibody or antibody against KATNB1 could matter depends on whether native KATNB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KATNB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KATNB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KATNB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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