Seroatlas · Human Serome Atlas

WSB2

WD repeat and SOCS box-containing protein 2

Also known as: MGC10210, SBA2, WSB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYS7
Gene: WSB2
Ensembl: ENSG00000176871
Chromosome: 12
Canonical length: 404 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>Q9NYS7|WSB2
     1  MEAGEEPLLL AELKPGRPHQ FDWKSSCETW SVAFSPDGSW FAWSQGHCIV KLIPWPLEEQ
    61  FIPKGFEAKS RSSKNETKGR GSPKEKTLDC GQIVWGLAFS PWPSPPSRKL WARHHPQVPD
   121  VSCLVLATGL NDGQIKIWEV QTGLLLLNLS GHQDVVRDLS FTPSGSLILV SASRDKTLRI
   181  WDLNKHGKQI QVLSGHLQWV YCCSISPDCS MLCSAAGEKS VFLWSMRSYT LIRKLEGHQS
   241  SVVSCDFSPD SALLVTASYD TNVIMWDPYT GERLRSLHHT QVDPAMDDSD VHISSLRSVC
   301  FSPEGLYLAT VADDRLLRIW ALELKTPIAF APMTNGLCCT FFPHGGVIAT GTRDGHVQFW
   361  TAPRVLSSLK HLCRKALRSF LTTYQVLALP IPKKMKEFLT YRTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WSB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 153 nTPM

Expression across tissuesHPA

Tissue

tongue: 153 nTPM
cerebral cortex: 145 nTPM
amygdala: 112 nTPM
skeletal muscle: 96 nTPM
hippocampal formation: 96 nTPM
spinal cord: 92 nTPM

Single-cell type

esophageal apical cells: 142 nCPM
urothelial cells: 99 nCPM
kupffer cells: 89 nCPM
alveolar cells type 1: 86 nCPM
parietal cells: 80 nCPM
colonocytes: 73 nCPM

Immune cell

eosinophil: 12 nTPM
basophil: 9.7 nTPM
intermediate monocyte: 7.5 nTPM
neutrophil: 5.4 nTPM
non-classical monocyte: 5.2 nTPM
T-reg: 5.1 nTPM

Brain region

midbrain: 192 nTPM
cerebral cortex: 182 nTPM
thalamus: 177 nTPM
medulla oblongata: 175 nTPM
hippocampal formation: 172 nTPM
pons: 170 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WSB2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 63 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Luo-Agrawal neurodevelopmental syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.93
gnomAD missense Z: 2.14
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WSB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WSB2 as an antibody target. Whether an autoantibody or antibody against WSB2 could matter depends on whether native WSB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WSB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WSB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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