Seroatlas · Human Serome Atlas

SMU1

WD40 repeat-containing protein SMU1

Also known as: BWD, FLJ10805, fSAP57, SMU-1, SMU1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAY7
Gene: SMU1
Ensembl: ENSG00000122692
Chromosome: 9
Canonical length: 513 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>Q2TAY7|SMU1
     1  MSIEIESSDV IRLIMQYLKE NSLHRALATL QEETTVSLNT VDSIESFVAD INSGHWDTVL
    61  QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT DPMIMLKQTQ PERYIHLENL
   121  LARSYFDPRE AYPDGSSKEK RRAAIAQALA GEVSVVPPSR LMALLGQALK WQQHQGLLPP
   181  GMTIDLFRGK AAVKDVEEEK FPTQLSRHIK FGQKSHVECA RFSPDGQYLV TGSVDGFIEV
   241  WNFTTGKIRK DLKYQAQDNF MMMDDAVLCM CFSRDTEMLA TGAQDGKIKV WKIQSGQCLR
   301  RFERAHSKGV TCLSFSKDSS QILSASFDQT IRIHGLKSGK TLKEFRGHSS FVNEATFTQD
   361  GHYIISASSD GTVKIWNMKT TECSNTFKSL GSTAGTDITV NSVILLPKNP EHFVVCNRSN
   421  TVVIMNMQGQ IVRSFSSGKR EGGDFVCCAL SPRGEWIYCV GEDFVLYCFS TVTGKLERTL
   481  TVHEKDVIGI AHHPHQNLIA TYSEDGLLKL WKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMU1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 15 nTPM
parathyroid gland: 15 nTPM
tonsil: 14 nTPM
skeletal muscle: 14 nTPM
thymus: 13 nTPM
ovary: 13 nTPM

Single-cell type

neutrophils: 135 nCPM
neutrophil progenitors: 97 nCPM
epicardial cells: 93 nCPM
syncytiotrophoblasts: 83 nCPM
endometrial luminal cells: 80 nCPM
monocyte progenitors: 77 nCPM

Immune cell

basophil: 23 nTPM
plasmacytoid DC: 20 nTPM
non-classical monocyte: 18 nTPM
myeloid DC: 16 nTPM
intermediate monocyte: 15 nTPM
naive CD8 T-cell: 14 nTPM

Brain region

white matter: 31 nTPM
cerebellum: 27 nTPM
spinal cord: 25 nTPM
basal ganglia: 24 nTPM
medulla oblongata: 24 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 4.31
DepMap mean gene effect: -2.75
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMU1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMU1 as an antibody target. Whether an autoantibody or antibody against SMU1 could matter depends on whether native SMU1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMU1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMU1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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