Seroatlas · Human Serome Atlas

STRAP

Serine-threonine kinase receptor-associated protein

Also known as: MAWD, pt-wd, STRAP_HUMAN, UNRIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y3F4
Gene
STRAP
Ensembl
ENSG00000023734
Chromosome
12
Canonical length
350 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium and spliceosomal snRNP assembly. Acts upstream of with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9Y3F4|STRAP
     1  MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG
    61  AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK HIVKTVDFTQ DSNYLLTGGQ
   121  DKLLRIYDLN KPEAEPKEIS GHTSGIKKAL WCSEDKQILS ADDKTVRLWD HATMTEVKSL
   181  NFNMSVSSME YIPEGEILVI TYGRSIAFHS AVSLDPIKSF EAPATINSAS LHPEKEFLVA
   241  GGEDFKLYKY DYNSGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTVVGKTY
   301  GLWKCVLPEE DSGELAKPKI GFPETTEEEL EEIASENSDC IFPSAPDVKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
128 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 128 nTPM
  • tongue: 107 nTPM
  • heart muscle: 87 nTPM
  • cerebral cortex: 81 nTPM
  • kidney: 79 nTPM
  • retina: 79 nTPM

Single-cell type

  • syncytiotrophoblasts: 397 nCPM
  • extravillous trophoblasts: 279 nCPM
  • megakaryocytes: 278 nCPM
  • platelets: 268 nCPM
  • esophageal suprabasal cells: 243 nCPM
  • decidual stromal cells: 234 nCPM

Immune cell

  • myeloid DC: 93 nTPM
  • T-reg: 92 nTPM
  • intermediate monocyte: 87 nTPM
  • total PBMC: 84 nTPM
  • non-classical monocyte: 81 nTPM
  • memory B-cell: 76 nTPM

Brain region

  • hypothalamus: 115 nTPM
  • pons: 109 nTPM
  • cerebral cortex: 95 nTPM
  • midbrain: 93 nTPM
  • hippocampal formation: 92 nTPM
  • thalamus: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.9
gnomAD missense Z
2.08
DepMap mean gene effect
-0.75
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STRAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STRAP as an antibody target. Whether an autoantibody or antibody against STRAP could matter depends on whether native STRAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STRAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STRAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STRAP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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