Seroatlas · Human Serome Atlas

DCAF11

DDB1- and CUL4-associated factor 11

Also known as: DCA11_HUMAN, GL014, PRO2389, WDR23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TEB1
Gene
DCAF11
Ensembl
ENSG00000100897
Chromosome
14
Canonical length
546 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>Q8TEB1|DCAF11
     1  MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG
    61  GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD TRELEFNEIK TQVELATGQL
   121  GLRRAAQKHS FPRMLHQRER GLCHRGSFSL GEQSRVISHF LPNDLGFTDS YSQKAFCGIY
   181  SKDGQIFMSA CQDQTIRLYD CRYGRFRKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD
   241  YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
   301  LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF
   361  IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA TQQNWDYRWQ QVPKKAWRKL
   421  KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT
   481  NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESEECAS APAPVPQSST
   541  PFSSPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • liver: 105 nTPM
  • skeletal muscle: 59 nTPM
  • pancreas: 56 nTPM
  • tongue: 47 nTPM
  • adrenal gland: 40 nTPM
  • kidney: 39 nTPM

Single-cell type

  • oligodendrocytes: 14 nCPM
  • bergmann glia: 14 nCPM
  • microglia: 14 nCPM
  • astrocytes: 13 nCPM
  • ependymal cells: 13 nCPM
  • brain excitatory neurons: 12 nCPM

Immune cell

  • NK-cell: 23 nTPM
  • eosinophil: 20 nTPM
  • myeloid DC: 17 nTPM
  • T-reg: 17 nTPM
  • intermediate monocyte: 16 nTPM
  • total PBMC: 15 nTPM

Brain region

  • cerebral cortex: 31 nTPM
  • thalamus: 31 nTPM
  • hippocampal formation: 31 nTPM
  • amygdala: 29 nTPM
  • basal ganglia: 29 nTPM
  • medulla oblongata: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.01
gnomAD missense Z
1.52
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF11 as an antibody target. Whether an autoantibody or antibody against DCAF11 could matter depends on whether native DCAF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCAF11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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