Seroatlas · Human Serome Atlas

WDR48

WD repeat-containing protein 48

Also known as: Bun62, KIAA1449, P80, SPG60, WDR48_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAF3
Gene
WDR48
Ensembl
ENSG00000114742
Chromosome
3
Canonical length
677 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>Q8TAF3|WDR48
     1  MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN
    61  QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV
   121  KALAYAKDKE LVASAGLDRQ IFLWDVNTLT ALTASNNTVT TSSLSGNKDS IYSLAMNQLG
   181  TIIVSGSTEK VLRVWDPRTC AKLMKLKGHT DNVKALLLNR DGTQCLSGSS DGTIRLWSLG
   241  QQRCIATYRV HDEGVWALQV NDAFTHVYSG GRDRKIYCTD LRNPDIRVLI CEEKAPVLKM
   301  ELDRSADPPP AIWVATTKST VNKWTLKGIH NFRASGDYDN DCTNPITPLC TQPDQVIKGG
   361  ASIIQCHILN DKRHILTKDT NNNVAYWDVL KACKVEDLGK VDFEDEIKKR FKMVYVPNWF
   421  SVDLKTGMLT ITLDESDCFA AWVSAKDAGF SSPDGSDPKL NLGGLLLQAL LEYWPRTHVN
   481  PMDEEENEVN HVNGEQENRV QKGNGYFQVP PHTPVIFGEA GGRTLFRLLC RDSGGETESM
   541  LLNETVPQWV IDITVDKNMP KFNKIPFYLQ PHASSGAKTL KKDRLSASDM LQVRKVMEHV
   601  YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP NMDLRTVKHF
   661  IWKSGGDLTL HYRQKST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • testis: 45 nTPM
  • bone marrow: 32 nTPM
  • thymus: 25 nTPM
  • thyroid gland: 23 nTPM
  • cerebral cortex: 22 nTPM
  • parathyroid gland: 21 nTPM

Single-cell type

  • late primary spermatocytes: 157 nCPM
  • late spermatids: 118 nCPM
  • neutrophils: 112 nCPM
  • endometrial glandular cells: 101 nCPM
  • differentiating spermatogonia: 88 nCPM
  • early spermatids: 87 nCPM

Immune cell

  • NK-cell: 15 nTPM
  • basophil: 13 nTPM
  • non-classical monocyte: 13 nTPM
  • T-reg: 13 nTPM
  • naive CD4 T-cell: 11 nTPM
  • memory CD8 T-cell: 11 nTPM

Brain region

  • white matter: 32 nTPM
  • hypothalamus: 31 nTPM
  • midbrain: 28 nTPM
  • basal ganglia: 28 nTPM
  • cerebral cortex: 28 nTPM
  • spinal cord: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
2.8
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR48 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR48 as an antibody target. Whether an autoantibody or antibody against WDR48 could matter depends on whether native WDR48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR48 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR48. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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